Publication:
Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone

Simple item page
dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorsGercek, Arzu; Yildirim, Ozlem; Konya, Deniz; Bozkurt, Suheyla; Ozgen, Serdar; Kilic, Turker; Sav, Aydin; Pamir, Necmettin
dc.date.accessioned2022-03-12T17:32:24Z
dc.date.available2022-03-12T17:32:24Z
dc.date.issued2007
dc.description.abstractBackground: The aim was to assess wound healing when parenteral fish-oil emulsion is given to rats receiving dexamethasone. Methods: For 5 days after skin wounding, group S (control; n = 7) received saline 1 mL/kg intraperitoneal (IP); group D (n = 7), dexamethasone 0.2 mg/kg IP; and group DO (n = 9), dexamethasone 0.2 mg/kg IP plus 1 mL/kg Omegaven (Fresenius Kabi, Austria). Wound specimens were assessed for hydroxyproline level, wound depth, histology (epidermal/dermal regeneration, granulation tissue thickness, and angiogenesis), and. expression of transforming growth factor-P (TGF-P) and platelet-derived growth factor-AA (PDGF-AA). Results: Compared with D and DO specimens, controls had higher hydroxyproline (p <.01), deeper wounds (p <.05), and better histologic scores (p <.01 angiogenesis; others p <.05). There were no significant differences between the group D and DO means for hydroxyproline level, wound depth, or histologic scores (p >.05 for all). Controls had higher TGF-P expression scores than the other groups (p <.01 for both) and a higher PDGF-AA expression score, than group DO (p <.01). Groups D and DO had statistically similar TGF-p scores, but group D had a higher PDGF-AA score (2.71 +/- 0.75 vs 1.55 +/- 0.72, respectively; p <.05). Conclusions: According to the parameters we studied, adding parenteral. omega-3 and omega-6 fatty acids to the nutrition regimen of rats treated with dexamethasone does not seem to have adverse effects on wound healing, and effects on wound healing may not need to be considered when determining if these agents should be supplemented in nutrition support regimens.
dc.identifier.doi10.1177/0148607107031003161
dc.identifier.eissn1941-2444
dc.identifier.issn0148-6071
dc.identifier.pubmed17463139
dc.identifier.urihttps://hdl.handle.net/11424/228568
dc.identifier.wosWOS:000248445100002
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofJOURNAL OF PARENTERAL AND ENTERAL NUTRITION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGROWTH-FACTOR-BETA
dc.subjectMESSENGER-RNA
dc.subjectFATTY-ACIDS
dc.subjectTISSUE
dc.subjectOMEGA-3-FATTY-ACIDS
dc.subjectINHIBITION
dc.subjectESOPHAGEAL
dc.subjectSINGLE
dc.subjectIMPACT
dc.subjectREPAIR
dc.titleEffects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e8b1ee2-d4f3-4b42-b888-fec4e18ad1f6
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage166
oaire.citation.issue3
oaire.citation.startPage161
oaire.citation.titleJOURNAL OF PARENTERAL AND ENTERAL NUTRITION
oaire.citation.volume31
relation.isAuthorOfPublicationdd039cf9-dfb8-4af0-b879-0b88c3a852fa
relation.isAuthorOfPublication.latestForDiscoverydd039cf9-dfb8-4af0-b879-0b88c3a852fa

Files

Collections

Research Outputs