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Effects of MC4R, FTO, and NMB Gene Variants to Obesity, Physical Activity, and Eating Behavior Phenotypes

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsKirac, Deniz; Cakir, Ozgur Kasimay; Avcilar, Tuba; Deyneli, Oguzhan; Kurtel, Hizir; Yazici, Dilek; Kaspar, Elif Cigdem; Celik, Nurgul; Guney, Ahmet Ilter
dc.date.accessioned2022-03-14T08:16:55Z
dc.date.available2022-03-14T08:16:55Z
dc.date.issued2016-10
dc.description.abstractObesity is a major contributory factor of morbidity and mortality. It has been suggested that biological systems may be involved in the tendency to be and to remain physically inactive also behaviors such as food and beverage preferences and nutrient intake may at least partially genetically determined. Consequently, besides environment, genetic factors may also contribute to the level of physical activity and eating behaviors thus effect obesity. Therefore the aim of this study is to investigate the effect of various gene mutations on obesity, physical activity levels and eating behavior phenotypes. One hundred patients and 100 controls were enrolled to the study. Physical activity levels were measured with an actical acceloremeter device. Eating behaviors were evaluated using Three-Factor Eating questionnaire (TFEQ). Associations between eating behavior scores and physical characteristics were also evaluated. The information about other obesity risk factors were also collected. Mutations were investigated with PCR, direct sequencing and Real-Time PCR. rs1051168, rs8050146-2778C>T mutations were found statistically significant in patients, rs1121980 was found statistically significant in controls. 21 mutations were found in MC4R and near MC4R of which 18 of them are novel and 8 of them cause amino acid change. In addition, it was found that, some obesity related factors and questions of TFEQ are associated with various investigated gene mutations. Any relation between gene mutations and physical activity levels were not detected. It is thought that, due to the genotype data and eating behaviors, it may be possible to recommend patients for proper eating patterns to prevent obesity. (C) 2016 IUBMB Life, 68(10):806-816, 2016
dc.identifier.doi10.1002/iub.1558
dc.identifier.eissn1521-6551
dc.identifier.issn1521-6543
dc.identifier.pubmed27634552
dc.identifier.urihttps://hdl.handle.net/11424/241411
dc.identifier.wosWOS:000388440500004
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofIUBMB LIFE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectobesity
dc.subjectphysical activity
dc.subjecteating behavior
dc.subjectFTO
dc.subjectMC4R
dc.subjectNMB
dc.subjectMELANOCORTIN-4 RECEPTOR GENE
dc.subjectBODY-MASS INDEX
dc.subjectNEUROMEDIN BETA
dc.subjectASSOCIATION
dc.subjectPOLYMORPHISM
dc.subjectADOLESCENTS
dc.subjectFAT
dc.subjectCHILDHOOD
dc.subjectMUTATIONS
dc.subjectCHILDREN
dc.titleEffects of MC4R, FTO, and NMB Gene Variants to Obesity, Physical Activity, and Eating Behavior Phenotypes
dc.typearticle
dspace.entity.typePublication
local.avesis.id8968d630-2ba5-406e-b6a7-23eae0683bd3
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
local.journal.quartileQ2
oaire.citation.endPage816
oaire.citation.issue10
oaire.citation.startPage806
oaire.citation.titleIUBMB LIFE
oaire.citation.volume68
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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