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Is Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes?

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dc.contributor.authorKAYA, HANDAN
dc.contributor.authorsCserni, Gabor; Zombori, Tamas; Andreu, Xavier; Bianchi, Simonetta; Regitnig, Peter; Amendoeira, Isabel; Balmativola, Davide; Kovacs, Aniko; Cordoba, Alicia; Reiner, Angelika; Kulka, Janina; Kaya, Handan; Liepniece-Karele, Inta; Quinn, Cecily; Kovari, Bence
dc.date.accessioned2022-03-14T09:03:44Z
dc.date.available2022-03-14T09:03:44Z
dc.date.issued2018-01
dc.description.abstractTumor draining sentinel lymph nodes (SLNs) are the sites of selective changes as compared to non-SLNs. They show features of tumor-reactive lymphadenopathy, including increased total number of functional blood vessels, but a relative immunosuppressed status has also been described in them. We explored the hypothesis of a selective regression or non-regression in SLNs versus non-SLNs in 142 patients with 110 estrogen receptor-positive and 32 estrogen receptor-negative tumors undergoing both SLN biopsy and axillary lymph node dissection after neoadjuvant therapy by assessing the tumoral (metastatic) and regression statuses of SLNs and non-SLNs separately. Of the 89 cases with signs of nodal regression, 22 cases (25%) were in favor of a selective non-regression in SLNs, 18 cases (20%) were supportive of a selective and more pronounced regression in the SLNs and the remaining showed equal degrees of regression or non-regression in SLNs and non-SLNs. The results indicate that there is no obvious difference in the degree of regressive histological changes shown by SLNs and NSLNs. Therefore, this phenomenon may not be a major contributor to the higher false negative rate of SLN biopsy after neoadjuvant treatment.
dc.identifier.doi10.1007/s12253-017-0229-z
dc.identifier.eissn1532-2807
dc.identifier.issn1219-4956
dc.identifier.pubmed28391512
dc.identifier.urihttps://hdl.handle.net/11424/242319
dc.identifier.wosWOS:000418404400021
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofPATHOLOGY & ONCOLOGY RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSentinel lymph node
dc.subjectNon-sentinel lymph node
dc.subjectBreast cancer
dc.subjectNeoadjuvant therapy
dc.subjectSelective regression
dc.titleIs Regression after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Different in Sentinel and Non-sentinel Nodes?
dc.typearticle
dspace.entity.typePublication
local.avesis.id74fe7a16-7c64-4e8c-adee-1234dab4a6dd
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages4
local.journal.quartileQ2
oaire.citation.endPage170
oaire.citation.issue1
oaire.citation.startPage167
oaire.citation.titlePATHOLOGY & ONCOLOGY RESEARCH
oaire.citation.volume24
relation.isAuthorOfPublication0bf301ff-2544-4a5e-b38b-b43084d6c255
relation.isAuthorOfPublication.latestForDiscovery0bf301ff-2544-4a5e-b38b-b43084d6c255

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