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A case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?

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dc.contributor.authorKAYA, MİTHAT
dc.contributor.authorGÖKCE, İBRAHİM
dc.contributor.authorALPAY, HARİKA
dc.contributor.authorsKAYA M., GÖKCE İ., Guven S., Pul S., ALPAY H.
dc.date.accessioned2023-12-15T05:25:29Z
dc.date.available2023-12-15T05:25:29Z
dc.date.issued2023-09-29
dc.description.abstractCoronavirus disease 2019 (COVID-19) was declared a global pandemic and a public health emergency worldwide in March 2020. COVID-19 presents with non-specific symptoms of the upper airway and pulmonary system, which can overlap with other diseases involving the respiratory system as granulomatosis with polyangiitis (GPA). Both diseases have high morbidity and mortality rates and it is important to promptly differentiate and treat them. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) is currently the recommended method for diagnosing COVID-19. Antibody-based tests are used to diagnose both pat and current COVID-19 infections. We present a previously healthy thirteen-year-old girl who was admitted with upper airway symptoms and pulmonary involvement, and progressed to acute kidney failure. Laboratory findings showed leukocytosis, anemia, elevated kidney function tests and 2+ proteinuria. Computed tomography (CT) of the lungs showed multiple nodules, cavities, and ground-glass opacities (GGOs). We performed RT-PCR tests for COVID-19 for three times. Results were all negative, but the COVID-19 immunoglobulin (Ig)M test sent simultaneously was positive. Based on the cytoplasmic antineutrophilic cytoplasmic antibody (c-ANCA) positivity, upper airway, pulmonary, and renal involvement, she was diagnosed as GPA. This report highlights that COVID-19 antibody tests can be false-positive in patients with autoimmune diseases including GPA.
dc.identifier.citationKAYA M., GÖKCE İ., Guven S., Pul S., ALPAY H., "A case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?", Marmara Medical Journal, cilt.36, sa.3, ss.373-376, 2023
dc.identifier.doi10.5472/marumj.1368360
dc.identifier.endpage376
dc.identifier.issn1019-1941
dc.identifier.issue3
dc.identifier.startpage373
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/c9bfed53-285e-4946-b47e-37faa64d6ff3/file
dc.identifier.urihttps://hdl.handle.net/11424/295648
dc.identifier.volume36
dc.language.isoeng
dc.relation.ispartofMarmara Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectCOVID-19
dc.subjectFalse-positive antibody test
dc.subjectGranulomatosis with polyangiitis
dc.titleA case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?
dc.typearticle
dspace.entity.typePublication
local.avesis.idc9bfed53-285e-4946-b47e-37faa64d6ff3
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery2c082502-dd9a-43fe-9116-7abb739de594

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