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Dual-Phase ADC Modelling of Breast Masses in Diffusion-Weighted Imaging: Comparison with Histopathologic Findings

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dc.contributor.authorBUĞDAYCI, ONUR
dc.contributor.authorsErtas, Gokhan; Onaygil, Can; Bugdayci, Onur; Aribal, Erkin
dc.date.accessioned2022-03-14T08:41:28Z
dc.date.available2022-03-14T08:41:28Z
dc.date.issued2018-05-16
dc.description.abstractObjective: To investigate the diagnostic value of dual-phase apparent diffusion coefficient (ADC) compared to traditional ADC values in quantitative diffusion-weighted imaging (DWI) for differentiating between benign and malignant breast masses. Materials and Methods: Diffusion-weighted images of pathologically confirmed 88 benign and 85 malignant lesions acquired using a 3.0T MR scanner were analyzed. Small region-of-interests focusing on the highest signal intensity of lesions were used. Lesion ADC estimates were obtained separately from all b-value images (ADC; b=50, 400 and 800s/mm(2)), lower b-value images (ADC low; b=50 and 400s/mm2) and higher b-value images (ADC(high); b=400 and 800s/mm(2)). A set of dual-phase ADC (dpADC) models were constructed using ADC low, ADC high and a perfusion influence factor ranging from 0 to 1. Results: Strong positive correlation is observable between ADC and all dpADCs (rho=0.80-1.00). Differences in ADC and dpADCs between the benign and the malignant lesions are all significant (p<0.05). In detecting malignancy, traditional lesion ADC provides a good performance (AUC=89.9%) however dpADC(0.5) (dpADC with a factor of 0.5) accomplishes a better performance (AUC=90.8%). At optimal thresholds, ADC achieves 94.1% sensitivity, 72.7% specificity and 83.2% accuracy while dpADC(0.5) leads to 92.9% sensitivity, 79.5% specificity and 86.1% accuracy. Conclusion: Dual-phase ADC modelling may improve the accuracy in breast cancer diagnosis using DWI. Further prospective studies are needed to justify its benefit in clinical setting.
dc.identifier.doi10.5152/ejbh.2018.3829
dc.identifier.eissn2587-0831
dc.identifier.pubmed29774316
dc.identifier.urihttps://hdl.handle.net/11424/242137
dc.identifier.wosWOS:000436143100007
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofEUROPEAN JOURNAL OF BREAST HEALTH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast
dc.subjectdiffusion-weighted imaging
dc.subjectapparent diffusion coefficient
dc.subjectdual-phase
dc.subjectINTRAVOXEL INCOHERENT MOTION
dc.subjectDIFFERENTIAL-DIAGNOSIS
dc.subjectCLINICAL-APPLICATIONS
dc.subjectCOEFFICIENT VALUES
dc.subject3.0 TESLA
dc.subjectMRI
dc.subjectCANCER
dc.subjectLESIONS
dc.subjectCHALLENGES
dc.subjectPRINCIPLES
dc.titleDual-Phase ADC Modelling of Breast Masses in Diffusion-Weighted Imaging: Comparison with Histopathologic Findings
dc.typearticle
dspace.entity.typePublication
local.avesis.id5e6b50d2-092e-425c-bb48-737c10fe31c0
local.import.packageSS16
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage92
oaire.citation.issue2
oaire.citation.startPage85
oaire.citation.titleEUROPEAN JOURNAL OF BREAST HEALTH
oaire.citation.volume14
relation.isAuthorOfPublication09a6d1f6-4818-4911-b69c-bd4ece9c9d3a
relation.isAuthorOfPublication.latestForDiscovery09a6d1f6-4818-4911-b69c-bd4ece9c9d3a

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