Publication:
Multidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsZengin, Gokhan; Ferrante, Claudio; Senkardes, Ismail; Gevrenova, Reneta; Zheleva-Dimitrova, Dimitrina; Menghini, Luigi; Orlando, Giustino; Recinella, Lucia; Chiavaroli, Annalisa; Leone, Sheila; Brunetti, Luigi; Picot-Allain, Carene Marie Nancy; Rengasamy, Kannan R. R.; Mahomoodally, Mohamad Fawzi
dc.date.accessioned2022-03-12T16:24:27Z
dc.date.available2022-03-12T16:24:27Z
dc.date.issued2019
dc.description.abstractIn the present study, the biological properties, including, the enzyme inhibitory and antioxidant activities, as well as, the phytochemical profile of the ethyl acetate, methanol, and water extracts of Rubus sanctus Schreb. and Rubus ibericus Juz. leaves were determined using in vitro bioassays. Wide range of phytochemicals, including, hydroxybenzoic acids, hydroxycinnamic acids, acylquinic acids, ellagitannins, flavonoids, and triterpenoid saponins were determined using UHPLC-ESI/HRMS technique. The ethyl acetate and methanol extracts of the studied Rubus species effectively inhibited acetyl and butyryl cholinesterase. On the other hand, R. sanctus water extract showed low inhibition against alpha-amylase and prominent inhibitory action against alpha-glucosidase. Data collected from this study reported the radical scavenging and reducing potential of the studied Rubus species. Investigation of the protective effects of the different extracts of R. sanctus and R. ibericus in experimental model of ulcerative colitis was performed. The extracts were also tested on spontaneous migration of human colon cancer cells (HCT116) in wound healing experimental paradigm. Only R. sanctus methanol extract inhibited spontaneous HCT116 migration in the wound healing test. Our results suggested that R. sanctus and R. ibericus may be potential candidates as sources of biologically-active compounds for the development of nutraceuticals, pharmaceuticals, and/or cosmetics.
dc.identifier.doi10.1016/j.fct.2019.03.041
dc.identifier.eissn1873-6351
dc.identifier.issn0278-6915
dc.identifier.pubmed30914354
dc.identifier.urihttps://hdl.handle.net/11424/226345
dc.identifier.wosWOS:000467512200027
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRubus
dc.subjectLC-MS
dc.subjectToxicity
dc.subjectAntioxidant
dc.subjectAnti-inflammatory
dc.subjectWound healing
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectLIPID-PEROXIDATION
dc.subjectOXIDATIVE STRESS
dc.subjectREACTIVE OXYGEN
dc.subjectCOREANUS
dc.subjectIDENTIFICATION
dc.subjectFLAVONES
dc.subjectEXTRACTS
dc.subjectCOLITIS
dc.titleMultidirectional biological investigation and phytochemical profile of Rubus sanctus and Rubus ibericus
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.idff7fddf3-5109-4cfc-9d0d-585835188075
local.conference.dateAUG 08-12, 2019
local.conference.locationGuangzhou, PEOPLES R CHINA
local.conference.sponsorJinan Univ, Zhejiang Univ, Univ Macau, Univ Hong Kong, Int Assoc Dietet Nutr & Safety, Int Soc Chinese Med
local.conference.title1st International Conference on Natural Toxicology and Pharmacology (ICNTP)
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages14
local.journal.quartileQ1
oaire.citation.endPage250
oaire.citation.startPage237
oaire.citation.titleFOOD AND CHEMICAL TOXICOLOGY
oaire.citation.volume127
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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