Publication:
Impact of valproate and levetiracetam exposure on GAERS behavior during pregnancy

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dc.contributor.authorTURGAN AŞIK, ZEHRA NUR
dc.contributor.authorKOYUNCUOĞLU, TÜRKAN
dc.contributor.authorKASIMAY ÇAKIR, ÖZGÜR
dc.contributor.authorsYAVUZ M., Kantarcı B. C., Şanlı A., Gavaş Ş., TURGAN AŞIK Z. N., KOYUNCUOĞLU T., KASIMAY Ö., ONAT F.
dc.date.accessioned2023-12-04T08:24:16Z
dc.date.available2023-12-04T08:24:16Z
dc.date.issued2023-09-01
dc.description.abstractObjective: Valproate (VPA) and levetiracetam (LEV) are frequently prescribed for the management of idiopathic generalized seizures; however, their well-documented teratogenic effects raise concerns when administered to pregnant epileptic patients. This study aimed to assess the impact of VPA and LEV exposure during pregnancy on Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Methods: Female GAERS rats were categorized into three groups: saline-treated (n=6), VPA-treated (200 mg/kg, n=4), and LEV-treated (50 mg/kg, n=6). Intraperitoneal injections were initiated from mating start and continued until partition. Locomotor activity and anxiety-like behavior were evaluated using open-field and hole-board tests for the VPA-treated and VPA-and LEV-treated groups; respectively. These tests were conducted both before and during pregnancy. Results: Across all groups, open-field testing demonstrated a tendency toward reduced locomotor activity parameters compared with pre-pregnancy, with VPA treatment showing significance (p<0.05). The hole-board test indicated a trend toward decreased rearing and hole exploration, coupled with increased freezing behavior in the saline-and VPA-treated groups. The LEV-treated group showed an elevation in freezing behavior and a decline in hole exploration. Conclusion: Although minimal effects on anxiety-like behaviors were noted in anti-seizure drug-treated rats, subtle tendencies were evident in the hole-board test. VPA and LEV administration resulted in depressive parameters in the locomotor activity test. These findings emphasize the need for caution when prescribing and using VPA and the LEV during pregnancy in terms of maternal behavior and mood.
dc.identifier.citationYAVUZ M., Kantarcı B. C., Şanlı A., Gavaş Ş., TURGAN AŞIK Z. N., KOYUNCUOĞLU T., KASIMAY Ö., ONAT F., "Impact of Valproate and Levetiracetam Exposure on GAERS Behavior During Pregnancy", Archives of Epilepsy, cilt.29, sa.3, ss.69-74, 2023
dc.identifier.doi10.4274/archepilepsy.2023.23098
dc.identifier.endpage74
dc.identifier.issn2792-0550
dc.identifier.issue3
dc.identifier.startpage69
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/2637cd0b-7e34-40a3-bb09-da1ae0ef08dc/file
dc.identifier.urihttps://hdl.handle.net/11424/295301
dc.identifier.volume29
dc.language.isoeng
dc.relation.ispartofArchives of Epilepsy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectCLINICAL NEUROLOGY
dc.subjectNöroloji (klinik)
dc.subjectYaşam Bilimleri
dc.subjectNeurology (clinical)
dc.subjectLife Sciences
dc.subjectGAERS
dc.subjectlevetiracetam
dc.subjectmaternal behavior
dc.subjectpregnancy
dc.subjectvalproic acid
dc.titleImpact of valproate and levetiracetam exposure on GAERS behavior during pregnancy
dc.typearticle
dspace.entity.typePublication
local.avesis.id2637cd0b-7e34-40a3-bb09-da1ae0ef08dc
local.indexed.atSCOPUS
relation.isAuthorOfPublicatione0890502-7210-4bd3-b8f6-a39eca7160c2
relation.isAuthorOfPublicatione146f762-5a31-46c5-a898-7594b85c6da6
relation.isAuthorOfPublication51d8b9ef-d750-4983-ac66-f5b9bc48fa31
relation.isAuthorOfPublication.latestForDiscoverye0890502-7210-4bd3-b8f6-a39eca7160c2

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