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Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra

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dc.contributor.authorÇAM, MUHAMMET EMİN
dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorsKirmizi Sonmez N. I. , Guler E., ÇAM M. E. , Ermanoglu M., Gurdal B., TAŞKIN T., Omurtag G. Z.
dc.date.accessioned2022-12-27T08:39:25Z
dc.date.available2022-12-27T08:39:25Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Marmara University Press.Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system.
dc.identifier.citationKirmizi Sonmez N. I. , Guler E., ÇAM M. E. , Ermanoglu M., Gurdal B., TAŞKIN T., Omurtag G. Z. , "Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra", Journal of Research in Pharmacy, cilt.26, sa.6, ss.1877-1883, 2022
dc.identifier.doi10.29228/jrp.277
dc.identifier.endpage1883
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.startpage1877
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142192458&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284224
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofJournal of Research in Pharmacy
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectanticonvulsant activity
dc.subjectantioxidant activity
dc.subjectepilepsy
dc.subjectHypericaceae
dc.subjectHypericum triquetrifolium Turra
dc.titleInvestigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra
dc.typearticle
dspace.entity.typePublication
local.avesis.id8c9a2057-6cab-4bc2-99a1-da5c910725cb
local.indexed.atSCOPUS
relation.isAuthorOfPublication96f1bd4e-81dc-4c34-bbf2-e15edc6f01b3
relation.isAuthorOfPublication265414e9-485c-42b8-903a-c467f6b49b84
relation.isAuthorOfPublication.latestForDiscovery96f1bd4e-81dc-4c34-bbf2-e15edc6f01b3

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