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Autoimmunity vs autoinflammation in Behcet's disease: do we oversimplify a complex disorder?

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Direskeneli - 2006 - Autoimmunity vs autoinflammation in Behcet's disea.pdf (120.96 KB)

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2006-08-18

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OXFORD UNIV PRESS

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Abstract

Behcet's disease (BD) is a systemic inflammatory disorder with a diverse spectrum of clinical manifestations including mucocutaneous, ocular, vascular, gastrointestinal, musculoskeletal and central nervous system involvement [1]. A complex genetic background leading to a pro-inflammatory, innate-immune-system-derived activation perpetuated by adaptive immune responses against enviromental and auto-antigens is accepted to be the hallmark of BD [2]. This review aims to make an in-depth critical analysis of current data for recent controversies on the role of innate immune system vs autoimmunity in BD [3-5].

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Behcet's disease, innate, adaptive, pathogenesis, HEAT-SHOCK PROTEINS, MONOSODIUM URATE CRYSTALS, T-CELL RESPONSES, DENDRITIC CELLS, PEPTIDE 336-351, ANTIGEN, UVEITIS, GAMMA, SKIN, IDENTIFICATION

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https://hdl.handle.net/11424/219968

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