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Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study

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dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsMoiseev, Sergey; Kronbichler, Andreas; Makarov, Egor; Bulanov, Nikolay; Crnogorac, Matija; Direskeneli, Haner; Galesic, Kresimir; Gazel, Ummugulsum; Geetha, Duvuru; Guillevin, Loic; Hruskova, Zdenka; Little, Mark A.; Ahmed, Adeel; McAdoo, Stephen P.; Mohammad, Aladdin J.; Moran, Sarah; Novikov, Pavel; Pusey, Charles D.; Rahmattulla, Chinar; Satrapova, Veronika; Silva, Joana; Terrier, Benjamin; Tesar, Vladimir; Westman, Kerstin; Jayne, David R. W.
dc.date.accessioned2022-03-12T22:59:18Z
dc.date.available2022-03-12T22:59:18Z
dc.date.issued2021
dc.description.abstractObjective. To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods. Patients with a definite diagnosis of AAV who were followed for at least 3months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results. Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15-60ml/min/1.73 m(2), OR 2.86 (95% CI: 1.27, 6.47); eGFR <15ml/min/1.73 m(2), OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion. Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE.
dc.identifier.doi10.1093/rheumatology/keab071
dc.identifier.eissn1462-0332
dc.identifier.issn1462-0324
dc.identifier.pubmed33523099
dc.identifier.urihttps://hdl.handle.net/11424/237296
dc.identifier.wosWOS:000709572600033
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.relation.ispartofRHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectANCA-associated vasculitis
dc.subjectvenous thromboembolic events
dc.subjectrisk factors
dc.subjectTHROMBOTIC EVENTS
dc.subjectRISK
dc.subjectGLUCOCORTICOIDS
dc.subjectGRANULOMATOSIS
dc.subjectDISEASE
dc.subjectPOLYANGIITIS
dc.subjectVALIDATION
dc.subjectMANAGEMENT
dc.subjectMORTALITY
dc.subjectINDEX
dc.titleAssociation of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study
dc.typearticle
dspace.entity.typePublication
local.avesis.id406eb90a-28db-4660-a666-8ae4782ffc78
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage4661
oaire.citation.issue10
oaire.citation.startPage4654
oaire.citation.titleRHEUMATOLOGY
oaire.citation.volume60
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

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