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Effect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans

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dc.contributor.authorGÜMRÜ TARÇIN, BİRSAY
dc.contributor.authorsUygun-Can, Banu; Kadir, Tanju; Gumru, Birsay
dc.date.accessioned2022-03-12T20:27:12Z
dc.date.available2022-03-12T20:27:12Z
dc.date.issued2016
dc.description.abstractObjective: Candida-associated denture stomatitis is the most prevalent form of oral candida infections among the denture wearers. Generally, antiseptic oral rinses used in the treatment of these infections are considered as an adjunct or alternative antifungal treatment. Studies have suggested that the intraoral concentrations of antiseptics decrease substantially to the sub-therapeutic levels on account of the dynamics of the oral cavity. This condition yields the question about the minimum antiseptic concentration that effect the character or pathogenesis of Candida during treatment. The extracellular phospholipase and proteinase enzymes of Candida albicans are regarded to have a crucial role in the pathogenesis of human fungal infections. Therefore, the aim of this study was to investigate the effect of different sub-therapeutic concentrations of chlorhexidine gluconate, hexetidine and triclosan on the production of these enzymes by C. albicans strains isolated from 20 patients with denture stomatitis. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Results: Exoenzyme production of 20 strains which were brief exposured to sub-therapeutic concentrations of three antiseptic agents decreased significantly compared with the strains that were not exposured with antiseptic values (p < 0.05). There was significant difference between the sub therapeutic concentrations of each of three antiseptics (p < 0.05). When the same concentrations of each antiseptic was compared, there were no significant differences between enzymatic activities (p > 0.05). Conclusions: The results of this study show that sub-therapeutic levels of each antiseptic may modulate candidal exoenzyme production, consequently suppressing pathogenicity of C albicans. (C) 2015 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.archoralbio.2015.11.006
dc.identifier.eissn1879-1506
dc.identifier.issn0003-9969
dc.identifier.pubmed26615573
dc.identifier.urihttps://hdl.handle.net/11424/233641
dc.identifier.wosWOS:000384514100003
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofARCHIVES OF ORAL BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCandida-associated denture stomatitis
dc.subjectChlorhexidine
dc.subjectHexetidine
dc.subjectTriclosan
dc.subjectExoenzymes
dc.subjectBUCCAL EPITHELIAL-CELLS
dc.subjectGERM TUBE FORMATION
dc.subjectCHLORHEXIDINE GLUCONATE
dc.subjectIN-VITRO
dc.subjectSUBTHERAPEUTIC CONCENTRATIONS
dc.subjectVIRULENCE FACTORS
dc.subjectBRIEF EXPOSURE
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectDENTURE STOMATITIS
dc.subjectMOUTH RINSES
dc.titleEffect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans
dc.typearticle
dspace.entity.typePublication
local.avesis.id20f06551-23ef-410b-9670-bccca212c9bf
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage27
oaire.citation.startPage20
oaire.citation.titleARCHIVES OF ORAL BIOLOGY
oaire.citation.volume62
relation.isAuthorOfPublication8063ed30-12e5-40ec-b1de-7de93b4a8c08
relation.isAuthorOfPublication.latestForDiscovery8063ed30-12e5-40ec-b1de-7de93b4a8c08

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