Publication:
Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients

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dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsYavuz, Dilek Gogas; Keskin, Lezan; Kiyici, Sinem; Sert, Murat; Yazici, Dilek; Sahin, Ibrahim; Yuksel, Meral; Deyneli, Oguzhan; Aydin, Hasan; Tuncel, Ercan; Akalin, Sema
dc.date.accessioned2022-03-12T18:04:56Z
dc.date.available2022-03-12T18:04:56Z
dc.date.issued2011
dc.description.abstractPrevious studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.
dc.identifier.doi10.1007/s00592-011-0284-y
dc.identifier.eissn1432-5233
dc.identifier.issn0940-5429
dc.identifier.pubmed21538164
dc.identifier.urihttps://hdl.handle.net/11424/230525
dc.identifier.wosWOS:000297515600009
dc.language.isoeng
dc.publisherSPRINGER-VERLAG ITALIA SRL
dc.relation.ispartofACTA DIABETOLOGICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectType 1 diabetes
dc.subjectVitamin D
dc.subjectVitamin D receptor gene polymorphisms
dc.subjectBone mineral density
dc.subjectASSOCIATION
dc.subjectPOPULATION
dc.subjectSUSCEPTIBILITY
dc.subjectOSTEOPOROSIS
dc.subjectPREVALENCE
dc.subjectOSTEOPENIA
dc.subjectMELLITUS
dc.subjectHEALTH
dc.subjectONSET
dc.titleVitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idcdcbb4c1-4b86-4fbb-8b61-04095d3a975b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage336
oaire.citation.issue4
oaire.citation.startPage329
oaire.citation.titleACTA DIABETOLOGICA
oaire.citation.volume48
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

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