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Amygdala kindling in the WAG/Rij rat model of absence epilepsy

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAker, RG; Yananli, HR; Gurbanova, AA; Ozkaynakci, AE; Ates, N; van Luijtelaar, G; Onat, FY
dc.date.accessioned2022-03-14T08:25:52Z
dc.date.available2022-03-14T08:25:52Z
dc.date.issued2006-01
dc.description.abstractPurpose: The kindling model in rats with genetic absence epilepsy is suitable for studying mechanisms involved in the propagation and generalization of seizure activity in the convulsive and nonconvulsive components of epilepsy. In the present study, we compared the amygdala kindling rate and afterdischarge characteristics of the nonepileptic Wistar control rat with a well-validated model of absence epilepsy, the WAG/Rij rat, and demonstrated the effect of amygdala kindling on spike-and-wave discharges (SWDs) in the WAG/Rij group. Methods: Electrodes were stereotaxically implanted into the basolateral amygdala of rats for stimulation and recording and into the cortex for recording. After a recovery period, the animals were stimulated at their afterdischarge thresholds. EEG was recorded to analyze SWDs and afterdischarge durations. The seizure severity was evaluated by using Racine's 5-stage scale. Results: All nonepileptic control and four of seven WAG/Rij animals reached a stage 5 seizure state, whereas three animals failed to reach stage 3, 4, or 5 and stayed at stage 2 after application of 30 stimulations. Interestingly, WAG/Rij rats, resistant to kindling, demonstrated a significantly longer duration of SWDs on the first day of the experiment before kindling stimulation than did the kindled WAG/Rij animals. Additionally, the cumulative total duration and the number of SWDs after the kindling stimulation were statistically increased compared with SWDs before kindling stimulation. Conclusions: The results of our study demonstrate that the progress of amygdala kindling is changed in rats with genetic absence epilepsy, perhaps as a consequence of the hundreds of daily SWDs.
dc.identifier.doi10.1111/j.1528-1167.2006.00367.x
dc.identifier.eissn1528-1167
dc.identifier.issn0013-9580
dc.identifier.pubmed16417529
dc.identifier.urihttps://hdl.handle.net/11424/241770
dc.identifier.wosWOS:000234403200005
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofEPILEPSIA
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectabsence epilepsy rats
dc.subjectspike-and-wave discharge
dc.subjectgeneralized epilepsy
dc.subjectpartial epilepsy
dc.subjectconvulsion
dc.subjectGAERS
dc.subjectSPIKE-WAVE DISCHARGES
dc.subjectELECTRICAL-STIMULATION
dc.subjectSEIZURES
dc.subjectCOEXISTENCE
dc.subjectEXCITATION
dc.subjectTHALAMUS
dc.subjectNEURONS
dc.subjectSTRAIN
dc.subjectCA1
dc.titleAmygdala kindling in the WAG/Rij rat model of absence epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id45c1118e-7c86-4a11-aef7-b964c0383dca
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage40
oaire.citation.issue1
oaire.citation.startPage33
oaire.citation.titleEPILEPSIA
oaire.citation.volume47
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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