Publication:
A New Biomarker on Bone Resorption in Chronic Otitis Media: Osteoprotegerin and NLRP3 Inflammasome Gene Polymorphisms

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dc.contributor.authorATA, PINAR
dc.contributor.authorsKeskin, Serhan; Tatlipinar, Arzu; Ata, Pinar
dc.date.accessioned2022-03-12T22:57:12Z
dc.date.available2022-03-12T22:57:12Z
dc.description.abstractChronic Otitis Media (COM) is a chronic inflammation of the middle ear and mastoid with persistent membrane perforation and hearing loss. Osteoprotegerin (OPG) and NOD like receptor protein 3 (NLRP3) play an important role in bone metabolism. The aim of the study was to investigate the role of OPG and NLRP3 gene polymorphism on ossicular chain resorption in COM. Fourty COM patients and 20 healhty control group were included in the study. While 20 patients underwent ossiculoplasty, 20 patients underwent type 1 tympanoplasty. DNA was isolated from peripheral blood using the DNA kit. OPG gene c.226A > C (p.Thr76Pro) and NLRP3 gene c.592G > A (p. Val198Met) polymorphisms were genotyped using melting curve analysis technique. NLRP3 gene polymorphism were determined in 6 of 20 patients (30%) in ossiculoplasty group, 4 of 20 patients (20%) in type 1 tympanoplasty group and 3 of 20 patients (15%) in control group. OPG gene polymorphism were determined in 5 of 20 patients (25%) in ossiculoplasty group, 3 of 20 patients (15%) in type 1 tympanoplasty group and 1 of 20 patients (5%) in control group, respectively. There was no statistically significant difference between groups regarding to results. Although the difference was not significant NLRP3 and OPG gene polymorphisms were higher in the ossiculoplasty group. Since NLRP3 and OPG gene polymorphisms were determined to be higher numerically in the ossiculoplasty group, OPG and NLRP3 gene regulation system may have an effect on ossicular chain destruction in COM.
dc.identifier.doi10.1007/s12070-021-02924-y
dc.identifier.eissn0973-7707
dc.identifier.issn2231-3796
dc.identifier.urihttps://hdl.handle.net/11424/237008
dc.identifier.wosWOS:000705778400004
dc.language.isoeng
dc.publisherSPRINGER INDIA
dc.relation.ispartofINDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTympanoplasty
dc.subjectOssiculoplasty
dc.subjectPolymorphism
dc.subjectOsteoprotegerin
dc.subjectNOD like receptor protein 3
dc.subjectMINERAL DENSITY
dc.subjectRANKL/RANK/OPG
dc.titleA New Biomarker on Bone Resorption in Chronic Otitis Media: Osteoprotegerin and NLRP3 Inflammasome Gene Polymorphisms
dc.typearticle
dspace.entity.typePublication
local.avesis.id030c404f-2989-4502-accd-7263cf2a8b28
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.titleINDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
relation.isAuthorOfPublication4ef620f9-0462-4687-84fa-c983fb788878
relation.isAuthorOfPublication.latestForDiscovery4ef620f9-0462-4687-84fa-c983fb788878

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