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Synthesis and Anticancer Activity of Some Novel Tolmetin Thiosemicarbazides

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dc.contributor.authorÖZSAVCI, DERYA
dc.contributor.authorsDadas, Yakup; Coskun, Goknil Pelin; Bingol-Akpinar, Ozlem; Ozsavci, Derya; Kucukguzel, S. Guniz
dc.date.accessioned2022-03-13T12:47:19Z
dc.date.available2022-03-13T12:47:19Z
dc.date.issued2015
dc.description.abstractA novel series of new ten tolmetin hydrazide derivatives, N-Alkyl/Arylsubstituted-2-{[1-methyl-5-(4-methylbenzoyl)-1H- pyrrol-2-yl]acetyl}hydrazinecarbothioamides [4a-j] have been synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR, H-1-NMR, C-13-NMR and 2D-NMR) methods and their purity were proven by elemental analysis and TLC. Tolmetin [1] and N-(4-fluorophenyl)-2-{[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2- yl] acetyl}hydrazinecarbothioamide [4d] were evaluated for in vitro using the MTT colorimetric method for anticancer activity. Androjen-independed human prostate cancer cell line PC-3 (ATCC, CRL-1435), human colon cancer cell lines HCT-116 (ATCC, CCL-247) and HT-29 (ATCC, HTB-38) were used in this study. Compound 4d exhibited anticancer activity against PC-3 whereas Tolmetin showed minor activity comparing to compound 4d.
dc.identifier.doi10.12991/mpj.201519328306
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/238057
dc.identifier.wosWOS:000365086900012
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjecttolmetin
dc.subjectthiosemicarbazide
dc.subjectPC-3
dc.subjectcolon cancer
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectBIOLOGICAL EVALUATION
dc.subjectCANCER
dc.subjectMATRIX
dc.subjectDERIVATIVES
dc.subjectCELLS
dc.titleSynthesis and Anticancer Activity of Some Novel Tolmetin Thiosemicarbazides
dc.typearticle
dspace.entity.typePublication
local.avesis.idb35dbd47-8f79-4318-b7ce-c0744bc5710f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage267
oaire.citation.issue3
oaire.citation.startPage259
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume19
relation.isAuthorOfPublication68ec1222-da29-4568-a8e5-56ebd6b48020
relation.isAuthorOfPublication.latestForDiscovery68ec1222-da29-4568-a8e5-56ebd6b48020

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