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Valuation of Neutrophil/Lymphocyte Ratio in Renal Cell Carcinoma Grading and Progression

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dc.contributor.authorAKDENİZ, ESRA
dc.contributor.authorsArda, Ersan; Yuksel, Ilkan; Cakiroglu, Basri; Akdeniz, Esra; Cilesiz, Nusret
dc.date.accessioned2022-03-14T09:03:14Z
dc.date.available2022-03-14T09:03:14Z
dc.date.issued2018-01-10
dc.description.abstractIntroduction We investigated the association of the neutrophil/lymphocyte ratio (NLR) with tumor size and Fuhrman grade in nonmetastatic renal cell carcinoma (RCC) cases. Materials and methods Data of nonmetastatic RCC (T1-4N0M0) cases, operated between 2010 and 2016, were retrospectively reviewed and 103 patients were included in the study. The patients were divided into two groups according to tumor diameter (Group 1 T < 4 cm, Group 2 T >= 4 cm) and into three groups according to Fuhrman grade. Twenty-eight patients with a tumor diameter of 4 cm or less in Group 1 and 75 patients with a tumor diameter greater than 4 cm in Group 2 were compared. In both grouping systems, the NLR, mean platelet volume (MPV), red cell distribution width (RDW), white blood cell (WBC), red blood cell (RBC), platelet (PLT), lymphocyte, and neutrophil values and age were compared. Results There were no differences in age, MPV, RDW, neutrophil, WBC, RBC, PLT counts in groups of tumor diameter (Group 1 T < 4 cm, Group 2 T >= 4 cm). However, the lymphocyte amount was significantly higher in cases with a tumor diameter less than 4 cm compared to the cases with a tumor diameter greater than 4 cm (p = 0.015). It was observed that the NLR had a tendency to increase in patients with tumor size greater than 4 cm compared to patients with tumor size smaller than 4 cm (p = 0.029). There were no differences in age, MPV, RDW, lymphocyte, neutrophil, WBC, RBC, PLT counts, and the NLR in different Fuhrman-graded cases. Conclusions There is a linear relation between the tumor size and the NLR in nonmetastatic RCC cases. Therefore, the NLR is a cheap parameter that can be used to show the tumor size, and thus it can be used to get an idea about the prognosis of the patient.
dc.identifier.doi10.7759/cureus.2051
dc.identifier.eissn2168-8184
dc.identifier.pubmed29541572
dc.identifier.urihttps://hdl.handle.net/11424/242240
dc.identifier.wosWOS:000450933700042
dc.language.isoeng
dc.publisherCUREUS INC
dc.relation.ispartofCUREUS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectneutrophil/lymphocyte ratio
dc.subjectrenal cell carcinoma
dc.subjectsize
dc.subjectprognosis
dc.subjectTO-LYMPHOCYTE RATIO
dc.subjectC-REACTIVE PROTEIN
dc.subjectLATE RECURRENCE
dc.subjectNEUTROPHIL
dc.subjectSURVIVAL
dc.titleValuation of Neutrophil/Lymphocyte Ratio in Renal Cell Carcinoma Grading and Progression
dc.typearticle
dspace.entity.typePublication
local.avesis.id9ec24ffc-c4af-469b-aee2-d918b16cbd53
local.import.packageSS16
local.indexed.atWOS
local.indexed.atPUBMED
local.journal.articlenumbere2051
local.journal.numberofpages9
oaire.citation.issue1
oaire.citation.titleCUREUS
oaire.citation.volume10
relation.isAuthorOfPublication247544af-fbb8-4147-a94d-b693a76513de
relation.isAuthorOfPublication.latestForDiscovery247544af-fbb8-4147-a94d-b693a76513de

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