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A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches

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dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorsCam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Cesur, Sumeyye; Ozkan, Ozan; Alenezi, Hussain; Sasmazel, Hilal Turkoglu; Eroglu, Mehmet Sayip; Brako, Francis; Ahmed, Jubair; Kabasakal, Levent; Ren, Guogang; Gunduz, Oguzhan; Edirisinghe, Mohan
dc.date.accessioned2022-03-14T09:29:00Z
dc.date.available2022-03-14T09:29:00Z
dc.date.issued2020-10
dc.description.abstractProgesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.
dc.identifier.doi10.1016/j.ijpharm.2020.119782
dc.identifier.eissn1873-3476
dc.identifier.issn0378-5173
dc.identifier.pubmed32822780
dc.identifier.urihttps://hdl.handle.net/11424/243179
dc.identifier.wosWOS:000576740600005
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofINTERNATIONAL JOURNAL OF PHARMACEUTICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProgesterone
dc.subjectPressurized gyration
dc.subjectElectrospinning
dc.subjectFibers
dc.subjectPolymeric patch
dc.subjectPreterm birth
dc.subjectIN-VITRO
dc.subjectPRESSURIZED GYRATION
dc.subjectDELIVERY
dc.subjectOVARIECTOMY
dc.subjectINHIBITION
dc.subjectNANOFIBERS
dc.subjectPREVENTION
dc.subjectESTRADIOL
dc.subjectMEMBRANES
dc.subjectAIR
dc.titleA novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches
dc.typearticle
dspace.entity.typePublication
local.avesis.idbaf2df92-5d01-4095-90c4-1c229ee3fc86
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber119782
local.journal.numberofpages15
local.journal.quartileQ1
oaire.citation.titleINTERNATIONAL JOURNAL OF PHARMACEUTICS
oaire.citation.volume588
relation.isAuthorOfPublication0bd18078-950c-4d8c-93f6-120ce419897d
relation.isAuthorOfPublication.latestForDiscovery0bd18078-950c-4d8c-93f6-120ce419897d

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