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The role of dopamine(2) receptor gene and personality characteristics in alcohol dependence in Turkish population

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dc.contributor.authorAKVARDAR, YILDIZ
dc.contributor.authorsDalmis, Arzu; Akvardar, Yildiz; Eresen, Cigdem; Kizildag, Sefa; Akpulat, Ugur; Yildirimcan, Sebnem; Arkar, Haluk; Akdede, Berna Binnur; Alptekin, Koksal
dc.date.accessioned2022-03-13T12:46:45Z
dc.date.available2022-03-13T12:46:45Z
dc.date.issued2014
dc.description.abstractObjective: Focusing on dopaminergic system, which is regarded to be responsible for alcohol dependence in many studies on animals and human beings, it is aimed to investigate Taql A and 8 allel polymorphisms of dopamine 2 receptor and personality characteristics in alcohol dependents and the relationship between these two parameters. Methods: In this study 64 alcohol dependent patients (3 females, 61 males) diagnosed according to DSM-IV diagnosis criteria, and 54 healthy subjects (8 females, 46 males) who themselves or whose first or second degree relatives had no alcohol dependence history were included. In order to determine their Taql A and 8 alleles, blood samples were drawn from the participants, and then they were applied Temperament and Character Inventory and Michigan Alcoholism Screening Test. Results: Subjects with and without alcohol dependence revealed no significant difference as regards the frequency of Taql A1 and B2 minor allel polymorphisms of DRD2 gene. It was also determined that the alcohol dependents had significantly higher scores in novelty seeking and harm avoidance dimensions, and lower scores in self directedness and cooperativeness dimensions than the controls. In alcohol dependents, no association was determined between the personality characteristics and Taql A1 and B2 minor allel polymorphisms. Conclusion: Not only one gene, but also several other minor genes in addition to personality characteristics and environment may play a role in vulnerability to alcohol dependence. In alcohol dependents, high novelty seeking is associated with the increase in impulsive behavior, and may be important for the onset of alcohol taking behavior. High level of harm avoidance may lead to taking alcohol continuously in order to deal with stress.
dc.identifier.doi10.5455/apd.44724
dc.identifier.issn1302-6631
dc.identifier.urihttps://hdl.handle.net/11424/237973
dc.identifier.wosWOS:000340477600002
dc.language.isotur
dc.publisherCUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI
dc.relation.ispartofANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlcohol dependence
dc.subjectgenetics
dc.subjectD-2 dopamine receptor gene (DRD2)
dc.subjectTemperament and Character Inventory
dc.subjectpersonality
dc.subjectALLELIC ASSOCIATION
dc.subjectNO ASSOCIATION
dc.subjectNOVELTY SEEKING
dc.subjectA1 ALLELE
dc.subjectD2
dc.subjectDRD2
dc.subjectPOLYMORPHISMS
dc.subjectTRAITS
dc.subjectDRUG
dc.subjectD-2
dc.titleThe role of dopamine(2) receptor gene and personality characteristics in alcohol dependence in Turkish population
dc.typearticle
dspace.entity.typePublication
local.avesis.id3171d447-7f8a-4854-a351-02237dfa6d02
local.import.packageSS17
local.indexed.atWOS
local.journal.numberofpages8
oaire.citation.endPage199
oaire.citation.issue3
oaire.citation.startPage192
oaire.citation.titleANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
oaire.citation.volume15
relation.isAuthorOfPublicationc1f03d86-0a2f-4362-bbe5-a3681b9f706f
relation.isAuthorOfPublication.latestForDiscoveryc1f03d86-0a2f-4362-bbe5-a3681b9f706f

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