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Determination of Pro-BNP and Troponin I Levels for ShortTerm Mortality Prediction in Ischemic Stroke Patients who did not Undergo Revascularization

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dc.contributor.authorÖZPOLAT, ÇİĞDEM
dc.contributor.authorONUR, ÖZGE ECMEL
dc.contributor.authorDENİZBAŞI ALTINOK, ARZU
dc.contributor.authorAKOĞLU, HALDUN
dc.contributor.authorsAydın N., Özpolat Ç., Onur Ö. E. , Akoğlu H., Denizbaşı Altınok A.
dc.date.accessioned2022-12-26T16:37:51Z
dc.date.available2022-12-26T16:37:51Z
dc.date.issued2022-01-01
dc.description.abstractIntroduction: Emergency departments (EDs) are the first place to start treatment for most stroke patients. Prognozing patients for planning and proper management of the therapies have an important place in approaching stroke patients. Many studies have been carried out with serum biomarkers especially in terms of prognosis stroke. Our objective, in this study, is to research short-term (14th day) mortality prediction of serum Troponin I (TnI) and pro-brain natriuretic peptide (BNP) levels. Methods: This was a prospective and observational prognostic test study. All consecutive patients admitted to the ED with the onset of symptoms in the past 24 h and diagnosed with the first episode of acute ischemic stroke were included in the study. A total of 121 subjects were included in the study. On admission, pro-BNP and TnI were collected from all subjects. On the 14th day of admission, patients were checked for mortality. Results: Of 121 patients, 14 (11.5%) had a mortal outcome at the end of the 14th day. The overall median pro-BNP level of all patients was 799.00 pg/ml (IQR: 220.00–2818.25). The median pro-BNP level of the non-survivor group was significantly higher than that of the survivor group (p:0.030). However, there was no significant difference between the TnI levels of the mortality groups. The optimal cutoff value of serum pro-BNP levels as an indicator of mortality on the 14th day was estimated to be 509 pg/ml (sensitivity: 85.7%, specificity: 49.5%, and AUC: 0.68 [95% CI, 0.59–0.769]). Discussion and Conclusion: Various biomarkers are investigated for prediction of mortality in ischemic stroke patient. According to our study, elevated pro-BNP values are associated with mortality. Further study with larger patient cohorts can be studied regarding the relationship between these threshold, in terms of predicting the mortality, in a more comprehensive study, as well as using subgroup and underlying conditions.
dc.identifier.citationAydın N., Özpolat Ç., Onur Ö. E. , Akoğlu H., Denizbaşı Altınok A., "Determination of Pro-BNP and Troponin I Levels for ShortTerm Mortality Prediction in Ischemic Stroke Patients who did not Undergo Revascularization", Haydarpaşa Numune Medical Journal, cilt.62, sa.2, ss.134-139, 2022
dc.identifier.doi10.14744/hnhj.2020.86658
dc.identifier.endpage139
dc.identifier.issn2630-5720
dc.identifier.issue2
dc.identifier.startpage134
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/3dc1294d-9463-4a0a-915b-a0164a64cd3f/file
dc.identifier.urihttps://hdl.handle.net/11424/284105
dc.identifier.volume62
dc.language.isoeng
dc.relation.ispartofHaydarpaşa Numune Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSağlık Bilimleri
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectClinical Medicine (MED)
dc.subjectIschemic stroke
dc.subjecttroponin I
dc.subjectpro-BNP
dc.subjectprognosis
dc.titleDetermination of Pro-BNP and Troponin I Levels for ShortTerm Mortality Prediction in Ischemic Stroke Patients who did not Undergo Revascularization
dc.typearticle
dspace.entity.typePublication
local.avesis.id3dc1294d-9463-4a0a-915b-a0164a64cd3f
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relation.isAuthorOfPublication.latestForDiscovery49a44509-1a25-4a10-bf29-147a09795c78

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