Publication:
Fabrication of gentamicin sulfate-loaded 3d-printed polyvinyl alcohol/sodium alginate/gelatin-methacryloyl hybrid scaffolds for skin tissue replacement

Simple item page
dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorAKSU, MEHMET BURAK
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsIzgordu M. S., Ayran M., ULAĞ S., Yildirim R., Bulut B., ŞAHİN A., Guncu M. M., AKSU M. B., GÜNDÜZ O.
dc.date.accessioned2023-10-30T07:29:47Z
dc.date.available2023-10-30T07:29:47Z
dc.date.issued2023-01-01
dc.description.abstract3D-printed scaffolds can better mimic the function of human skin, both biologically and mechanically. Within the scope of this study, the effect of the addition of different amounts (10, 15, 20 mg) of gentamicin sulfate (GS) to a 10 mL solution of natural and synthetic polymers is investigated. Sodium alginate (SA), gelatin-methacryloyl (GelMA), and polyvinyl alcohol (PVA) are chosen as bioactive materials. The surface morphology and pore structures are visualized by scanning electron microscopy (SEM). According to the results, it is observed that the pore sizes of all scaffolds are smaller than 270 µm, the lowest value (130 µm) is obtained in the scaffold loaded with 15 mg GS, and it also has the highest tensile strength value (12.5 ± 7.6 MPa). Similarly, it is observed that the tensile strength (9.7 ± 4.5 MPa) is high in scaffold loaded with 20 mg GS. The biocompatibility test is performed with fibroblast cells, and the results show that the scaffolds are biocompatible with cells. The antibacterial test is carried out against the S.aureous and E. coli and the results indicate that all GS-loaded scaffolds demonstrate antibacterial activity.
dc.identifier.citationIzgordu M. S., Ayran M., ULAĞ S., Yildirim R., Bulut B., ŞAHİN A., Guncu M. M., AKSU M. B., GÜNDÜZ O., "Fabrication of Gentamicin Sulfate-Loaded 3D-Printed Polyvinyl Alcohol/Sodium Alginate/Gelatin-Methacryloyl Hybrid Scaffolds for Skin Tissue Replacement", Macromolecular Materials and Engineering, 2023
dc.identifier.doi10.1002/mame.202300151
dc.identifier.issn1438-7492
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174567132&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/294489
dc.language.isoeng
dc.relation.ispartofMacromolecular Materials and Engineering
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemical Engineering and Technology
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectPOLİMER BİLİMİ
dc.subjectKİMYA, ORGANİK
dc.subjectMALZEME BİLİMİ, ÇOKDİSİPLİNLİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectCHEMISTRY
dc.subjectENGINEERING, CHEMICAL
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY, ORGANIC
dc.subjectMATERIALS SCIENCE, MULTIDISCIPLINARY
dc.subjectGenel Kimya Mühendisliği
dc.subjectFizik Bilimleri
dc.subjectPolimerler ve Plastikler
dc.subjectOrganik Kimya
dc.subjectMalzeme Kimyası
dc.subjectGeneral Chemical Engineering
dc.subjectPhysical Sciences
dc.subjectPolymers and Plastics
dc.subjectOrganic Chemistry
dc.subjectMaterials Chemistry
dc.subject3D printing
dc.subjectalginate
dc.subjectgelatin
dc.subjectPVA
dc.subjectscaffold
dc.subjectskin tissue
dc.titleFabrication of gentamicin sulfate-loaded 3d-printed polyvinyl alcohol/sodium alginate/gelatin-methacryloyl hybrid scaffolds for skin tissue replacement
dc.typearticle
dspace.entity.typePublication
local.avesis.idff2c2e65-8fe3-4473-b7ab-45a6d263a85b
local.indexed.atSCOPUS
relation.isAuthorOfPublication7694c253-e59a-4111-abfb-dcb9eed6d6f8
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublicationf7de5699-7a5c-4496-93cf-d8daba79da4f
relation.isAuthorOfPublication88c4b483-9bfd-4c78-8f3b-bab559753b35
relation.isAuthorOfPublication.latestForDiscovery7694c253-e59a-4111-abfb-dcb9eed6d6f8

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
11.pdf
Size:
2.77 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs