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Adenoid ‘ameloblastoma: Clinicopathological description of 4 additional BRAF-negative cases

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dc.contributor.authorCİNEL, ZELİHA LEYLA
dc.contributor.authorsKhalaj F., CİNEL Z. L., Aminishakib P., Mosavat F., SOLUK TEKKEŞİN M.
dc.date.accessioned2023-11-13T07:34:09Z
dc.date.available2023-11-13T07:34:09Z
dc.date.issued2023-12-01
dc.description.abstractObjective: Adenoid ameloblastoma (AA) is an epithelial odontogenic tumor that was recognized as a separate entity in the last odontogenic classification of WHO in 2022. The etiology is unknown, and the pathogenesis remains controversial. The objective of this study is to contribute the clinicopathological features of 4 additional BRAF-negative cases to the existing literature, aiming to enhance the molecular understanding of this unique tumor in the forthcoming classification. Materials and methods: This study consists of a case series of four patients diagnosed with AA. The patients’ demographic and clinical information were collected from the universities’ medical achieves. Histopathologically, all cases were reexamined according to the latest update of the WHO odontogenic tumor classification. In addition to H&E and immunohistochemical stains, cytogenetics was also evaluated. Results: Well-defined unilocular radiolucent lesions were observed in all cases. Ameloblastoma-like components exhibited reserved nuclear polarity, suprabasal stellate reticulum-like epithelium, duct-like structure, whorls/morules, and cribriform architecture were common features. Variable immunoreactivity to CK7, CK19, CK14, p63, and p40 were determined, and proliferative activity was greater than 15%. The BRAF molecular study revealed no mutations. Conclusions: When diagnosing AA, the essential histopathological characteristics must be rigorously applied, and a significant portion of the lesion should contain these features. Additionally, despite limited molecular data, since the BRAF mutation commonly observed in ameloblastomas is not present in the majority of AA cases, we propose changing the term \"ameloblastoma\" to \"ameloblastic\" and referring to it as \"adenoid ameloblastic tumor\" in the forthcoming classification.
dc.identifier.citationKhalaj F., CİNEL Z. L., Aminishakib P., Mosavat F., SOLUK TEKKEŞİN M., "Adenoid ‘ameloblastoma’: Clinicopathological description of 4 additional BRAF-negative cases", Journal of Stomatology, Oral and Maxillofacial Surgery, cilt.124, sa.6, 2023
dc.identifier.doi10.1016/j.jormas.2023.101585
dc.identifier.issn2468-7855
dc.identifier.issue6
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85175619719&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/294788
dc.identifier.volume124
dc.language.isoeng
dc.relation.ispartofJournal of Stomatology, Oral and Maxillofacial Surgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKulak Burun Boğaz
dc.subjectDiş Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectOtolaryngology
dc.subjectDentistry
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectKULAK BURUN BOĞAZ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectDENTISTRY, ORAL SURGERY & MEDICINE
dc.subjectOTORHINOLARYNGOLOGY
dc.subjectCerrahi
dc.subjectAğız Cerrahisi
dc.subjectSurgery
dc.subjectOral Surgery
dc.subjectOtorhinolaryngology
dc.subjectAdenoid ameloblastoma
dc.subjectBRAF p.V600E
dc.subjectOdontogenic tumor
dc.subjectWHO
dc.titleAdenoid ‘ameloblastoma: Clinicopathological description of 4 additional BRAF-negative cases
dc.typearticle
dspace.entity.typePublication
local.avesis.id2c481f3a-4224-4946-ad90-fd643ca88503
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication9625d7c6-4046-41d3-85cc-c9e2f41b7df2
relation.isAuthorOfPublication.latestForDiscovery9625d7c6-4046-41d3-85cc-c9e2f41b7df2

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