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Synthesis of Diflunisal Thiazolidinones as Anticancer Agents

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dc.contributor.authorŞENER, AZİZE
dc.contributor.authorsSenkardes, Sevil; Ozakpinar, Ozlem B.; Ozsavci, Derya; Sener, Azize; Cevik, Ozge; Kucukguzel, S. Guniz
dc.date.accessioned2022-03-12T20:27:57Z
dc.date.available2022-03-12T20:27:57Z
dc.date.issued2016
dc.description.abstractA series of diflunisal 4-thiazolidinones were synthesized. Some selected compounds were determined at one dose towards the full panel of 60 human cancer cell lines by National Cancer Institute. 2',4'-Difluoro-4-hydroxy-N-[4-oxo-2-(thiophen-2-yl)-1,3-thiazolidin-3-yl]biphenyl-3-carboxamide (4a) demonstrated the most marked effect on K-562 cancer cell line with 58.59 % growth inhibition at 10 mu M. Compound 4a was evaluated in vitro using the MTT colorimetric method against human leukemia cell line K-562 and mouse embryonic fibroblasts cell line NIH-3T3 at different doses for cell viability and growth inhibition. Compound 4a exhibited anticancer activity with IC50 value of 5.2 mu M against K-562 cells and did not display cytotoxicity towards NIH-3T3 cells compared with diflunisal. In addition, this compound could be an interesting prototype as an antiproliferative agent.
dc.identifier.doi10.2174/1871520615666150831125337
dc.identifier.eissn1875-5992
dc.identifier.issn1871-5206
dc.identifier.pubmed26320814
dc.identifier.urihttps://hdl.handle.net/11424/233815
dc.identifier.wosWOS:000382267900005
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnnexin-V
dc.subjectapoptosis
dc.subjectdiflunisal
dc.subjectK-562 cancer cell line
dc.subject4-Thiazolidinone
dc.subjectNATIONAL-CANCER-INSTITUTE
dc.subjectHYDRAZIDE-HYDRAZONES
dc.subjectCASPASE ACTIVATION
dc.subjectDRUG DISCOVERY
dc.subjectAPOPTOSIS
dc.subjectCYTOTOXICITY
dc.subjectDERIVATIVES
dc.subjectMECHANISMS
dc.subjectSCREEN
dc.subjectCELLS
dc.titleSynthesis of Diflunisal Thiazolidinones as Anticancer Agents
dc.typearticle
dspace.entity.typePublication
local.avesis.id1549f9d9-4925-4599-a1ec-719f82118a8b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage1274
oaire.citation.issue10
oaire.citation.startPage1266
oaire.citation.titleANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
oaire.citation.volume16
relation.isAuthorOfPublicationfd65174e-4126-41c3-913d-e8bcdce20632
relation.isAuthorOfPublication.latestForDiscoveryfd65174e-4126-41c3-913d-e8bcdce20632

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