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Development and In Vitro Evaluation of a Novel Pulsatile Drug Delivery System Containing Dexketoprofen Trometamol

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dc.contributor.authorUĞURLU, TİMUÇİN
dc.contributor.authorsUgurlu, Timucin; Ilhan, Ezgi
dc.date.accessioned2022-03-12T22:40:19Z
dc.date.available2022-03-12T22:40:19Z
dc.date.issued2021
dc.description.abstractPurpose A pulsatile drug delivery system containing dexketoprofen trometamol was designed by combining immediate release and colon-targeted mini tablets into a capsule. Methods Both immediate release and colon-targeted mini tablets were prepared by wet granulation. Furthermore, colon-targeted mini tablets were coated with Eudragit L 100, Eudragit S 100, Eudragit RS 30D, and ethylcellulose (Surelease (R)) using Wurster and pan coating methods. Results The optimum drug release of the system developed in the study was found to be mini tablets coated with 30% Eudragit S 100 on a 20% Surelease (R) subcoating for the purpose of colon targeting. Conclusion In the finished product, the immediate release part released the drug within the first hour, and less than 5% release was observed from the colon-targeted tablets in a 0.1 N HCl in 2 h. Then, less than 20% release occurred in the colon-targeted tablets up to 6 h in pH 6.8 phosphate buffer solution. The cumulative release rate reached 100% for up to 12 h. To our knowledge, it was the first time dexketoprofen trometamol was designed by combining both immediate release and colon-targeted mini tablets in a one dosage form.
dc.identifier.doi10.1007/s12247-020-09452-2
dc.identifier.eissn1939-8042
dc.identifier.issn1872-5120
dc.identifier.urihttps://hdl.handle.net/11424/235940
dc.identifier.wosWOS:000537341800001
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL INNOVATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDexketoprofen trometamol
dc.subjectMini tablet
dc.subjectColon targeting
dc.subjectChronotherapy
dc.subjectRheumatoid arthritis
dc.subjectPulsatile release
dc.subjectINTESTINAL PH
dc.subjectRELEASE
dc.subjectTIME
dc.subjectPOLYMERS
dc.subjectDESIGN
dc.subjectOPTIMIZATION
dc.subjectPERFORMANCE
dc.titleDevelopment and In Vitro Evaluation of a Novel Pulsatile Drug Delivery System Containing Dexketoprofen Trometamol
dc.typearticle
dspace.entity.typePublication
local.avesis.id4fbf1488-8820-4deb-b012-156bd86ea0ce
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages13
local.journal.quartileQ3
oaire.citation.endPage383
oaire.citation.issue2
oaire.citation.startPage371
oaire.citation.titleJOURNAL OF PHARMACEUTICAL INNOVATION
oaire.citation.volume16
relation.isAuthorOfPublication0f48a4ac-c964-4c96-ab96-c6a811cbbbf3
relation.isAuthorOfPublication.latestForDiscovery0f48a4ac-c964-4c96-ab96-c6a811cbbbf3

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