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Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsGoger, Gamze; Allak, Muhammed; Sen, Ali; Goger, Fatih; Tekin, Mehmet; Ozek, Gulmira
dc.date.accessioned2022-03-12T22:57:35Z
dc.date.available2022-03-12T22:57:35Z
dc.date.issued2021
dc.description.abstractPhytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and beta-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and alpha-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 mu g/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 mu g/mL, whereas, CAD showed the best inhibition of a-glucosidase with an IC50 value of 396.40 mu g/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 mu g/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.
dc.identifier.doi10.1515/znc-2020-0257
dc.identifier.eissn1865-7125
dc.identifier.issn0939-5075
dc.identifier.pubmed33559461
dc.identifier.urihttps://hdl.handle.net/11424/237065
dc.identifier.wosWOS:000672580800006
dc.language.isoeng
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectactivity
dc.subjectCota altissima
dc.subjectessential oil
dc.subjectextract
dc.subjectGC-MS/FID
dc.subjectLC-MS/MS
dc.subjectCHEMICAL-COMPOSITION
dc.subjectESSENTIAL OIL
dc.subjectANTHEMIS-ALTISSIMA
dc.subjectINHIBITORY-ACTIVITIES
dc.subjectACID
dc.subjectCLASSIFICATION
dc.subjectWIEDEMANNIANA
dc.subjectCHRYSANTHEMUM
dc.subjectCULTIVARS
dc.subjectPROFILES
dc.titleAssessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities
dc.typearticle
dspace.entity.typePublication
local.avesis.id834eca68-8c06-4c88-bdaf-d99d9a007a47
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage327
oaire.citation.issue7-8
oaire.citation.startPage317
oaire.citation.titleZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
oaire.citation.volume76
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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