Publication: Ultrasonography and duplex doppler ultrasonography based indices in nodular thyroid disease
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Date
2013-10-01
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Abstract
Background. Fine needle
aspiration biopsy (FNAB) is an important
tool in the diagnosis of thyroid nodules.
Aim. Our aim was to investigate
the malignancy criteria in thyroid nodules
by gray-scale ultrasonography (US) and
duplex Doppler ultrasonography (DDUS),
and their usefulness in reducing the number
of unnecessary FNAB’s.
Study design. This was a
prospective observational study.
Subjects and methods. 181
benign and 18 malignant thyroid nodules
were evaluated by US and DDUS before
FNAB or thyroidectomy. US was used to
note size, shape, internal structure, nodule
echogenicity, marginal properties, peripheral
hypoechogenic halo, and microcalcifications.
DDUS studies were used to evaluate the
maximum and minimum flow velocity (Vmax
and Vmin), systolic/diastolic flow velocity
ratio (S/D), pulsatility index (PI), resistive
index (RI), acceleration time (AT) and
acceleration value.
Results. Contour irregularity,
size and presence of microcalcifications
(p<0.001, p=0.02 and p=0.002, respectively)
and S/D, Vmin, PI, RI and AT were
significantly different (p=0.004, p=0.007,
p=0.032, p=0.003 and p=0.003, respectively)
were significant for malignant nodules.
Benign and malignant nodules with or
without suspicious US findings had similar
DDUS findings. Vmax, Vmin, PI, RI, and AT
were significantly different in the presence
of microcalcification (p=0.043, p=0.001,
p=0.031, p=0.04, and p=0.019 respectively).
AT was significantly different in the case
of absence of microcalcification (p=0.019).
Comparing the irregular margins, Vmin, PI
and RI were significantly different (p=0.014,
p=0.003, and p=0.014 respectively).
Conclusion. Benign and malignant
thyroid nodules can be differentiated using
gray-scale US findings and DDUS based
indices together to reduce the number of
unnecessary FNAB’s.
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Keywords
Tıp, Dahili Tıp Bilimleri, İç Hastalıkları, Endokrinoloji ve Metabolizma Hastalıkları, Sağlık Bilimleri, Medicine, Internal Medicine Sciences, Internal Diseases, Endocrinology and Metabolic Diseases, Health Sciences, ENDOKRİNOLOJİ VE METABOLİZMA, Klinik Tıp, Klinik Tıp (MED), ENDOCRINOLOGY & METABOLISM, CLINICAL MEDICINE, Clinical Medicine (MED), Endokrin ve Otonom Sistemler, Endokrinoloji, Diyabet ve Metabolizma, Endokrinoloji, Yaşam Bilimleri, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Endocrinology, Life Sciences, thyroid, thyroid cancer, ultrasonography, duplex Doppler ultrasonography, thyroid nodule, acceleration time, FINE-NEEDLE-ASPIRATION, CONVENTIONAL ULTRASONOGRAPHY, DIFFERENTIAL-DIAGNOSIS, PREDICTING MALIGNANCY, GRAY-SCALE, CARCINOMA, US, SONOGRAPHY, BENIGN, ULTRASOUND, thyroid, thyroid cancer, ultrasonography, duplex Doppler ultrasonography, thyroid nodule, acceleration time.
Citation
ASLAN A., Sancak S., ASLAN M., ÇİMŞİT N. Ç. , GÜLLÜOĞLU M. B. , Ahiskali R. A. , Akalin N. S. , ARIBAL M. E. , "ULTRASONOGRAPHY AND DUPLEX DOPPLER ULTRASONOGRAPHY BASED INDICES IN NODULAR THYROID DISEASE", ACTA ENDOCRINOLOGICA-BUCHAREST, cilt.9, sa.4, ss.575-588, 2013