Publication:
Oral health is a mediator for disease severity in patients with Behcet's disease: A multiple mediation analysis study

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dc.contributor.authorAKSOY, AYSUN
dc.contributor.authorsYay, Meral; Celik, Zulal; Aksoy, Aysun; Alibaz-Oner, Fatma; Inanc, Nevsun; Ergun, Tulin; Direskeneli, Haner; Mumcu, Gonca
dc.date.accessioned2022-03-12T22:38:07Z
dc.date.available2022-03-12T22:38:07Z
dc.date.issued2019
dc.description.abstractObjectivesThe aim of the study was to examine whether oral health as an infection focus could mediate disease course in patients with Behcet's disease (BD). MethodsIn the study, oral health of 194 BD patients was examined at baseline and follow-up periods. The reasons for last dental visits were recorded as tooth extraction or regular control visits/planned treatments at the end of follow-up period. The Behcet's disease severity score was calculated with higher scores indicating a more severe course. Mediation analysis was carried out to assess the effects of oral health on disease severity score at follow-up period in the study. ResultsDental and periodontal indices were found to be higher at follow-up visit compared to those of baseline (P<0.05). Disease severity score was found to be higher in males (5.32.4) compared to females (4.4 +/- 2.5) in the whole group (P=0.005). Moreover, patients having tooth extraction at their last dental visit and patients with dental caries had a more severe disease course (5.4 +/- 2.4; 5.5 +/- 2.5) compared to others (4.2 +/- 2.3; 4.4 +/- 2.4; P<0.0001). In multiple mediation analysis, disease severity score was a dependent variable and was directly mediated by male gender (B=-0.8822, P=0.0145) and indirectly mediated through the presence of dental caries (B=0.9509 P=0.0110) and need of tooth extraction (B=0.8758, P=0.0128). ConclusionBoth presence of dental caries and need of tooth extraction were observed to be effective mediators for a more severe disease course in BD. Therefore, better oral health should be aimed to eliminate microbial factors, which are a part of pathogenic processes.
dc.identifier.doi10.1111/joor.12750
dc.identifier.eissn1365-2842
dc.identifier.issn0305-182X
dc.identifier.pubmed30466164
dc.identifier.urihttps://hdl.handle.net/11424/235500
dc.identifier.wosWOS:000461582900006
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF ORAL REHABILITATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's disease
dc.subjectgender
dc.subjectmediation analysis
dc.subjectoral health
dc.subjectoral hygiene education
dc.subjecttreatment
dc.subjectPERIODONTAL FINDINGS
dc.subjectINFECTIOUS ETIOLOGY
dc.subjectSALIVARY LEVELS
dc.subjectULCER ACTIVITY
dc.subjectHNP 1-3
dc.subjectASSOCIATION
dc.subjectPATHOGENESIS
dc.subjectSTRATEGIES
dc.titleOral health is a mediator for disease severity in patients with Behcet's disease: A multiple mediation analysis study
dc.typearticle
dspace.entity.typePublication
local.avesis.ide1659002-6f06-4b5f-8edb-a37e5eb1ef3a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ2
oaire.citation.endPage354
oaire.citation.issue4
oaire.citation.startPage349
oaire.citation.titleJOURNAL OF ORAL REHABILITATION
oaire.citation.volume46
relation.isAuthorOfPublication8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72
relation.isAuthorOfPublication.latestForDiscovery8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72

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