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Multiparametric breast MRI with 3T: Effectivity of combination of contrast enhanced MRI, DWI and 1H single voxel spectroscopy in differentiation of Breast tumors

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dc.contributor.authorKAYA, HANDAN
dc.contributor.authorsAribal, Erkin; Asadov, Ruslan; Ramazan, Abdullah; Ugurlu, Mustafa Umit; Kaya, Handan
dc.date.accessioned2022-03-12T20:28:00Z
dc.date.available2022-03-12T20:28:00Z
dc.date.issued2016
dc.description.abstractObjectives: To evaluate the diagnostic accuracy of dynamic contrast enhanced breast MRI (DCE-MRI) combined with diffusion weighted imaging (DWI) and 1H single-voxel magnetic resonance spectroscopy (1HMRS) in differentiating malignant from benign breast lesions. Methods: One hundred twenty-nine patients with 138 lesions were included in the study. Multiparametric MRI of the breast was performed with a 3T unit. A DWI is followed by DCE-MRI and 1HMRS. All lesions were biopsied within one week after MRI. Histopathologic findings were accepted as the standard of reference. Probability of malignancy was assessed according to BI-RADS for DCE-MRI. ADC values were measured for DWI and choline peaks were assessed using a semi-quantitative method in 1HMRS. Two blinded radiologists evaluated findings in consensus. Diagnostic performance of DCE-MRI, DWI and 1HMRS alone or in combination for multiparametric imaging were statistically evaluated. Results: Histopathology revealed malignancy in 54.4% of lesions (75/138). DCE-MRI showed the highest AUC (0.978), sensitivity (97.33%) and specificity (88.89%) compared to DWI and 1HMRS. Sensitivity was 100% when a positive result from any one of three techniques was accepted as malignancy, albeit with a trade-off for 65.1% specificity. Highest specificity (98.4%) was attained when all three techniques were required to be positive, though with a lower sensitivity (82.7%) as trade-off. Logistic regression analysis confirmed significant association with DCE-MRI (p < 0.001) and 1H MRS (p = 0.009) but not with DWI (p = 0.127). There was one case of fat necrosis which was false positive in all three techniques. Conclusions: Multiparametric imaging with combination of DCE-MRI, DWI and 1HMRS does not improve, and may even reduce the diagnostic accuracy of breast MRI. Although, the specificity may be improved with a trade-off for lower sensitivity, we have not set a convenient algorithm for the combined use of these techniques. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejrad.2016.02.022
dc.identifier.eissn1872-7727
dc.identifier.issn0720-048X
dc.identifier.pubmed27130059
dc.identifier.urihttps://hdl.handle.net/11424/233826
dc.identifier.wosWOS:000375140500014
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofEUROPEAN JOURNAL OF RADIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast cancer
dc.subjectMultiparametric MRI
dc.subjectDynamic contrast enhanced magnetic
dc.subjectresonance imaging
dc.subjectDiffusion weighted imaging
dc.subject1H single voxel MR spectroscopy
dc.subjectFat necrosis
dc.subjectMucinous cancer
dc.subjectAPPARENT DIFFUSION-COEFFICIENT
dc.subjectDIAGNOSIS
dc.subjectLESIONS
dc.subjectBENIGN
dc.subjectMETAANALYSIS
dc.subjectACCURACY
dc.titleMultiparametric breast MRI with 3T: Effectivity of combination of contrast enhanced MRI, DWI and 1H single voxel spectroscopy in differentiation of Breast tumors
dc.typearticle
dspace.entity.typePublication
local.avesis.idbde9eb9a-e022-48a4-96de-13bab091895b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage986
oaire.citation.issue5
oaire.citation.startPage979
oaire.citation.titleEUROPEAN JOURNAL OF RADIOLOGY
oaire.citation.volume85
relation.isAuthorOfPublication0bf301ff-2544-4a5e-b38b-b43084d6c255
relation.isAuthorOfPublication.latestForDiscovery0bf301ff-2544-4a5e-b38b-b43084d6c255

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