Publication:
Controlled Release of Metformin Loaded Polyvinyl Alcohol (PVA) Microbubble/Nanoparticles Using Microfluidic Device for the Treatment of Type 2 Diabetes Mellitus

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dc.contributor.authorSAYIN, FATİH SERDAR
dc.contributor.authorsCesur S., Cam M.E., Sayın F.S., Su S., Gunduz O.
dc.date.accessioned2022-03-15T02:15:52Z
dc.date.available2022-03-15T02:15:52Z
dc.date.issued2020
dc.description.abstractNowadays it became obvious that a relentless increase in Type 2 diabetes mellitus (T2DM), affecting the economically affluent countries, is gradually afflicting also the developing world. The currently used drugs in the treatment of T2DM have inefficient glucose control and carry serious side effects. In this study, nano-sized uniform particles were produced by microfluidic method by the explosion of microbubbles. Morphological (SEM), molecular interactions between the components (FT-IR), drug release test by UV spectroscopy measurement were carried out after production process. When microbubbles and nanoparticles, optical microscope and SEM images obtained were examined, it was observed that metformin was successfully loaded into nanoparticles. The diameter of the microbubbles and nanoparticles was 104 ± 91 µm and 116 ± 13 nm, respectively. Metformin was released in a controlled manner at pH 1.2 for 390 min. It is promising in the treatment of T2DM with the controlled release ability of metformin loaded nonoparticles. © Springer Nature Switzerland AG 2020.
dc.identifier.doi10.1007/978-3-030-45385-5_17
dc.identifier.isbn9783030453848
dc.identifier.issn3029743
dc.identifier.urihttps://hdl.handle.net/11424/248168
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes mellitus
dc.subjectDrug delivery
dc.subjectMicrobubble
dc.subjectNanoparticle
dc.subjectT-junction
dc.titleControlled Release of Metformin Loaded Polyvinyl Alcohol (PVA) Microbubble/Nanoparticles Using Microfluidic Device for the Treatment of Type 2 Diabetes Mellitus
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.idfb9fa092-b95d-4e3e-b215-8e6a0b8c6fe9
local.conference.title8th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2020
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
oaire.citation.endPage193
oaire.citation.startPage185
oaire.citation.titleLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
oaire.citation.volume12108 LNBI
relation.isAuthorOfPublicationb714b7d3-c910-4dfa-a847-fbee38f6b9c3
relation.isAuthorOfPublication.latestForDiscoveryb714b7d3-c910-4dfa-a847-fbee38f6b9c3

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