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Prevalence of HIV-associated neurocognitive disorder (HAND) in Turkey and assessment of Addenbrooke's Cognitive Examination Revised (ACE-R) test as a screening tool

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dc.contributor.authorTİGEN, ELİF
dc.contributor.authorsKorten, V; Ay, U.; Hari, E.; Tigen Tukenmez, E.; Gencer, S.; Akca Kalem, S.; Demirtas Tatlidede, A.; Gurvit, I. H.
dc.date.accessioned2022-03-12T22:44:49Z
dc.date.available2022-03-12T22:44:49Z
dc.date.issued2021
dc.description.abstractObjectives We aimed to assess the Addenbrooke's Cognitive Examination Revised (ACE-R) and three questions (3Qs, European Aids Clinical Society Guidelines) as potential screening tools for HIV-associated neurocognitive disorder (HAND). In addition, we tried to determine the prevalence and associated factors for HAND among people living with HIV (PLWH) in Turkey. Methods Persons living with HIV were enrolled from two teaching hospitals between March 2018 and September 2018. Participants underwent screening tools, a neuropsychological test battery (NTB) and an assessment of activities of daily living. HAND was diagnosed according to Frascati's criteria and applying the Global Deficit Score (GDS) approach. A receiver operating characteristic (ROC) curve analysis was performed to compare the predictive accuracy of ACE-R to that of the NP test battery. Factors associated with HAND were evaluated using multivariate logistic regression analysis. Results The study sample included 162 participants (94% male). The HAND prevalence was 45.7% [asymptomatic neurocognitive impairment (ANI), 37.7%; mild neurocognitive disorder (MND), 7.4%; HIV-associated dementia (HAD), 0.6%] according to the Frascati criteria and 31.5% (ANI, 25.9%; MND, 4.9%; HAD, 0.6%) using the GDS. In the ROC analysis, the ACE-R showed an area under the curve of 0.68 at a cut-off score of 89. The sensitivity, specificity and correct classification rate of screening tests for HAND diagnosis were as follows: ACE-R (62.2%, 67%, 64.8%) and 3Qs (10.8%, 88.6%, 53%). In multivariate analysis, only education level (adjusted odds ratio [aOR] = 0.84, 95% CI: 0.76-0.92,P <= 0.001) was an independent risk factor for HAND. Conclusions HAND is a common comorbidity in PLWH in Turkey. The sensitivities and specificities of 3Qs and the ACE-R as screening tools are lower than desired.
dc.identifier.doi10.1111/hiv.12957
dc.identifier.eissn1468-1293
dc.identifier.issn1464-2662
dc.identifier.pubmed32964651
dc.identifier.urihttps://hdl.handle.net/11424/236468
dc.identifier.wosWOS:000571822900001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofHIV MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAddenbrooke's cognitive examination
dc.subjectCPE score
dc.subjectHIV-associated neurocognitive disorder
dc.subjectneurocognitive impairment
dc.subjectneuropsychological testing
dc.subjectscreening tool
dc.subjectANTIRETROVIRAL THERAPY
dc.subjectIMPAIRMENT
dc.subjectDEMENTIA
dc.subjectERA
dc.titlePrevalence of HIV-associated neurocognitive disorder (HAND) in Turkey and assessment of Addenbrooke's Cognitive Examination Revised (ACE-R) test as a screening tool
dc.typearticle
dspace.entity.typePublication
local.avesis.idb2d00beb-1919-41c7-831b-9cb829984153
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ3
oaire.citation.endPage66
oaire.citation.issue1
oaire.citation.startPage60
oaire.citation.titleHIV MEDICINE
oaire.citation.volume22
relation.isAuthorOfPublicationfad8e847-d87e-49b7-ad74-3ff14b50ed24
relation.isAuthorOfPublication.latestForDiscoveryfad8e847-d87e-49b7-ad74-3ff14b50ed24

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