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Effect of perinatal biotin deficiency on auditory pathway of the Wistar-Albino rats

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dc.contributor.authorKAYA, ÖZLEM TUĞÇE
dc.contributor.authorsYllmaz, Nevreste Didem Sonbay; Gur, Ozer Erdem; Ensari, Nuray; Bulut, Erdogan; Kaya, Ozlem Tugce; Sirvanci, Serap; Danisman, Betul; Derin, Narin; Gezgin, Bahri; Aygener, Nurdan; Yilmaz, Mustafa Deniz
dc.date.accessioned2022-03-12T22:39:16Z
dc.date.available2022-03-12T22:39:16Z
dc.date.issued2019
dc.description.abstractAim: Severe biotin deficiency associated with biotinidase enzyme deficiency in newborns is seen as severe neurological problems and hearing loss. However, the effect on the infant of deficiencies in the maternal diet during pregnancy are not clear. Material and methods: The study included 16 female Wistar albino rats and 4 male Wistar albino rats, that were mated and then the females were separated into 4 groups. At 40 days after the birth, 3 pups were selected from each group, and these 12 pups were evaluated with DPOAE and ABR electrophysiologically and the cochlea was examined ultrastructurally with electron microscopy. Results: In the DPOAE evaluation, At 8000 and 11,000 Hz, the signal-noise ratios in the B-N and B-B groups were statistically significantly higher (p < .05). In ABR, lengthening of the latency periods was determined in all the waves at both 8 and 16 kHz in the B-B group. When the IPL periods were examined, lengthening in IPL 1-5 was statistically significant in the B-B group only at 8 kHz. Conclusions: Biotin can be said to have an effect on hearing pathways. However, specifically where on the hearing pathways that biotin is involved has not been clarified.
dc.identifier.doi10.1080/00016489.2019.1614665
dc.identifier.eissn1651-2251
dc.identifier.issn0001-6489
dc.identifier.pubmed31124733
dc.identifier.urihttps://hdl.handle.net/11424/235795
dc.identifier.wosWOS:000469711200001
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofACTA OTO-LARYNGOLOGICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiotin
dc.subjecthearing pathway
dc.subjectDPOAE
dc.subjectABR
dc.subjectelectron microscopy
dc.subjectHEARING-LOSS
dc.subjectDEAFNESS
dc.titleEffect of perinatal biotin deficiency on auditory pathway of the Wistar-Albino rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id1aafbb2a-4ea6-40ec-aa7c-3ef3a1b446b4
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ4
oaire.citation.endPage684
oaire.citation.issue8
oaire.citation.startPage677
oaire.citation.titleACTA OTO-LARYNGOLOGICA
oaire.citation.volume139
relation.isAuthorOfPublicationd9b3e5d1-ec49-49ec-887a-14cd84eb73f6
relation.isAuthorOfPublication.latestForDiscoveryd9b3e5d1-ec49-49ec-887a-14cd84eb73f6

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