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Impact of a clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy in older hospitalized patients: a non-randomized controlled study

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dc.contributor.authorOKUYAN, BETÜL
dc.contributor.authorsDumlu H. I., Sancar M., Ozdemir A., Okuyan B.
dc.date.accessioned2023-04-26T06:16:58Z
dc.date.available2023-04-26T06:16:58Z
dc.date.issued2022-08-01
dc.description.abstractBackground The potentially inappropriate use of the proton pump inhibitors is prevalent in older adults. Aim To evaluate the impact of a clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy in older hospitalized patients. Method This parallel nonrandomized controlled study was conducted at an internal medicine service of a tertiary training and research hospital between September 2019 and August 2021. Older patients (>= 65 years old and received proton pump inhibitors within 48 h of admission) were allocated to two groups according to their number of medical file records, whether odd or even, two groups: control and clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy (including medication reconciliation and medication review) during the hospital stay. Primary outcome measures were the rate of appropriate use of proton pump inhibitors during hospitalization and potentially inappropriate proton pump inhibitor use at discharge. Results The rate of appropriate proton pump inhibitor use during hospitalization was significantly higher in the clinical pharmacist-led program (n = 100) than in the control group (n = 97) (46.4% vs. 79.0%; P < 0.001). The rate of potentially inappropriate proton pump inhibitor use at discharge was significantly lower (61.7% vs. 35.1%; P < 0.05) in the clinical pharmacist-led program among the older patients discharged with a proton pump inhibitor prescription. Conclusions A clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy improved the rate of appropriate proton pump inhibitor use and reduced the potentially inappropriate proton pump inhibitor use during the hospital stay.
dc.identifier.citationDumlu H. I., Sancar M., Ozdemir A., Okuyan B., "Impact of a clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy in older hospitalized patients: a non-randomized controlled study.", International journal of clinical pharmacy, cilt.44, sa.4, ss.914-921, 2022
dc.identifier.doi10.1007/s11096-022-01394-8
dc.identifier.endpage921
dc.identifier.issn2210-7703
dc.identifier.issue4
dc.identifier.startpage914
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/35449351/
dc.identifier.urihttps://hdl.handle.net/11424/288932
dc.identifier.volume44
dc.language.isoeng
dc.relation.ispartofInternational journal of clinical pharmacy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectProton pump inhibitor
dc.subjectGeriatric
dc.subjectMedication review
dc.subjectPotentially inappropriate medication
dc.subjectPROTON PUMP INHIBITORS
dc.subjectSTRESS-ULCER PROPHYLAXIS
dc.subjectIMPROVE
dc.subjectDISEASE
dc.titleImpact of a clinical pharmacist-led stewardship program for the appropriate use of acid suppression therapy in older hospitalized patients: a non-randomized controlled study
dc.typearticle
dspace.entity.typePublication
local.avesis.idbc5f722f-5039-4ebe-bd7b-c4c32ca6b692
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationf6e7969a-ea61-403f-8772-1a8478556223
relation.isAuthorOfPublication.latestForDiscoveryf6e7969a-ea61-403f-8772-1a8478556223

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