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Fabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats

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dc.contributor.authorKABASAKAL, LEVENT
dc.contributor.authorsCam, Muhammet Emin; Cesur, Sumeyye; Taskin, Turgut; Erdemir, Gokce; Kuruca, Durdane Serap; Sahin, Yesim Muge; Kabasakal, Levent; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:39:13Z
dc.date.available2022-03-12T22:39:13Z
dc.date.issued2019
dc.description.abstractThe use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In this study, the characterization and performance of electrospun Achillea lycaonica-loaded (0.125, 0.250 and 0.500, wt%) poly (lactic acid) (PLA) (8%, w/v) nanofibrous mats for skin tissue engineering were investigated. SEM, FTIR, DSC, and tensile strength test of the electrospun nanofibers have been investigated. Drug releasing test and cell culture study were also carried out. Achillea lycaonica-loaded nanofibrous mats in 0.250 (wt%) and 0.500 (wt%) demonstrated excellent cell compatibility and increased the viability of NIH/3T3 (mouse embryo fibroblast) cells within 72 h. According to the results, Achillea lycaonica-loaded PLA nanofibers have proper tensile strength and controlled release. The working temperature range enlarged for the composites having higher plant extract content. Consequently, Achillea lycaonica-loaded nanofibrous mats have a great potential in skin tissue engineering applications.
dc.identifier.doi10.1016/j.eurpolymj.2019.109239
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/11424/235788
dc.identifier.wosWOS:000498309000038
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectrospinning
dc.subjectAchillea lycaonica
dc.subjectNanofibers
dc.subjectPolylactic acid
dc.subjectFibroblast proliferation
dc.subjectSkin tissue engineering
dc.subjectINDOCYANINE GREEN
dc.subjectAQUEOUS EXTRACT
dc.subjectHEALING-PROCESS
dc.subjectESSENTIAL OIL
dc.subjectANTIOXIDANT
dc.subjectMILLEFOLIUM
dc.subjectYARROW
dc.titleFabrication, characterization and fibroblast proliferative activity of electrospun Achillea lycaonica-loaded nanofibrous mats
dc.typearticle
dspace.entity.typePublication
local.avesis.id919a8a22-4465-4e5a-8f5a-12a60e116bca
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber109239
local.journal.numberofpages7
local.journal.quartileQ1
oaire.citation.titleEUROPEAN POLYMER JOURNAL
oaire.citation.volume120
relation.isAuthorOfPublication95119e87-e1fe-479a-b594-419fda7d5214
relation.isAuthorOfPublication.latestForDiscovery95119e87-e1fe-479a-b594-419fda7d5214

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