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Adrenomedullin reduces the severity of cerulein-induced acute pancreatitis

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dc.contributor.authorDENİZBAŞI ALTINOK, ARZU
dc.contributor.authorsOnur, Ozge Ecmel; Guneysel, Ozlem; Akoglu, Haldun; Denizbasi, Arzu; Onur, Ender
dc.date.accessioned2022-03-12T17:32:52Z
dc.date.available2022-03-12T17:32:52Z
dc.date.issued2007
dc.description.abstractWe investigated the effect of Adrenomedullin (AM) on cerulein-induced acute pancreatitis in rats. AM treatment (100 ng/kg per rat, subcutaneous) after one hour of cerulein injection reduced the plasma amylase levels, pancreatic weight, pancreatic malondialdehyde (MDA) levels, and the severity of the lesions microscopically. These data suggest that AM has a protective effect on cerulein-induced acute pancreatitis. These could be due to anti-inflammatory properties of AM, inhibition of proinflammatory cytokine secretion, reducing the endothelial permeability increased by reactive oxygen species, endotoxins or cytokines. (C) 2007 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.peptides.2007.08.028
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pubmed17928102
dc.identifier.urihttps://hdl.handle.net/11424/228710
dc.identifier.wosWOS:000251104300011
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofPEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectadrenomedullin
dc.subjectacute pancreatitis
dc.subjectcerulein
dc.subjectBINDING PROTEIN-1
dc.subjectMACROPHAGE
dc.subjectCYTOKINES
dc.subjectUROCORTIN
dc.subjectINJURY
dc.titleAdrenomedullin reduces the severity of cerulein-induced acute pancreatitis
dc.typearticle
dspace.entity.typePublication
local.avesis.idd33b3a10-7f2d-4433-a8ca-6fc76166f252
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage2183
oaire.citation.issue11
oaire.citation.startPage2179
oaire.citation.titlePEPTIDES
oaire.citation.volume28
relation.isAuthorOfPublication85d7879a-b827-49ad-8b5f-77e6661077c7
relation.isAuthorOfPublication.latestForDiscovery85d7879a-b827-49ad-8b5f-77e6661077c7

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