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Rickets in the Middle East: Role of environment and genetic predisposition

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dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorsBaroncelli, Giampiero I.; Bereket, Abdullah; El Kholy, Mohamed; Audi, Laura; Cesur, Yasar; Ozkan, Behzat; Rashad, Mona; Fernandez-Cancio, Monica; Weisman, Yoseph; Saggese, Giuseppe; Hochberg, Ze'ev
dc.date.accessioned2022-03-14T08:17:20Z
dc.date.available2022-03-14T08:17:20Z
dc.date.issued2008-05-01
dc.description.abstractContext: The Middle East has a high incidence of rickets, and it is also common in Europe-dwelling children of Middle Eastern origin. Objective: The objective of the study was to explore the mechanisms leading to rickets in children of the Middle East. Design and Setting: We conducted a prospective study in 98 rachitic and 50 controls (aged 6 months to 4 yr) from university and community outpatient hospitals in Egypt and Turkey. Main Outcome Measures: We collected epidemiological, maternal, nutritional, radiographic, and biochemical parameters; markers of bone turnover; and vitamin D receptor (VDR) gene polymorphisms. Results: Epidemiological factors had a key role in pursuit of rickets; Egyptian and Turkish patients had lower (P < 0.01) dietary calcium intake than controls and the recommended dietary intakes, and serum 25-hydroxyvitamin D levels were reduced in patients, the difference with controls being significant (P < 0.001) only in Turkey, although rickets was more severe in Egypt as determined by the x-ray score (P < 0.05). In Turkey, the F VDR allele frequency was significantly (P < 0.05) increased in patients. The BB VDR genotype was associated with lower serum 25-hydroxyvitamin D levels in both patients and controls and with severity of rickets. Conclusions: In Turkey most patients had vitamin D deficiency, whereas in Egypt they had mostly calcium insufficiency combined with vitamin D deficiency. In this environ, VDR genotypes may predispose to rickets by increased frequency of the F allele. The unique environs and genetic predisposition have to be accounted for in the design of preventive measures, rather than using European or American recommended dietary intake for calcium and vitamin D.
dc.identifier.doi10.1210/jc.2007-1413
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.pubmed18285415
dc.identifier.urihttps://hdl.handle.net/11424/241437
dc.identifier.wosWOS:000255663100030
dc.language.isoeng
dc.publisherENDOCRINE SOC
dc.relation.ispartofJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVITAMIN-D-RECEPTOR
dc.subjectBONE-MINERAL DENSITY
dc.subjectNUTRITIONAL RICKETS
dc.subjectD DEFICIENCY
dc.subjectDIETARY CALCIUM
dc.subjectPARATHYROID-HORMONE
dc.subjectCHILDREN
dc.subjectPOLYMORPHISM
dc.subject25-HYDROXYVITAMIN-D
dc.subjectPREVALENCE
dc.titleRickets in the Middle East: Role of environment and genetic predisposition
dc.typearticle
dspace.entity.typePublication
local.avesis.idbc1a831d-029b-4489-ba77-f2aaaffb0ed1
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage1750
oaire.citation.issue5
oaire.citation.startPage1743
oaire.citation.titleJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
oaire.citation.volume93
relation.isAuthorOfPublication669e9474-4e39-453f-a4bc-4ede9cb5abac
relation.isAuthorOfPublication.latestForDiscovery669e9474-4e39-453f-a4bc-4ede9cb5abac

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