Publication:
Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsTarcin, Ozlem; Yavuz, Dilek Gogas; Ozben, Beste; Telli, Ahu; Ogunc, Ayliz Velioglu; Yuksel, Meral; Toprak, Ahmet; Yazici, Dilek; Sancak, Seda; Deyneli, Oguzhan; Akalin, Sema
dc.date.accessioned2022-03-14T09:14:54Z
dc.date.available2022-03-14T09:14:54Z
dc.date.issued2009-10-01
dc.description.abstractContext: Vitamin D receptors are present in many tissues. Hypovitaminosis D is considered to be a risk factor for atherosclerosis. Objective: This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects. Design, Setting, and Patients: Twenty-three asymptomatic vitamin D-deficient subjects with 25-hydroxyvitamin D [25(OH)D] levels below 25 nmol/liter were compared with a control group that had a mean 25(OH)D level of 75 nmol/liter. The vitamin D-deficient group received 300,000 IU im monthly for 3 months. The following parameters were evaluated before and after treatment: vitamin D metabolites, leptin, endothelial function by brachial artery flow mediated dilatation (FMD), insulin sensitivity index based on oral glucose tolerance test, and lipid peroxidation as measures of thiobarbituric acid reactive substances (TBARS). Results: FMD measurements were significantly lower in 25(OH)D-deficient subjects than controls (P = 0.001) and improved after replacement therapy (P = 0.002). Posttreatment values of TBARS were significantly lower than pretreatment levels (P < 0.001). A positive correlation between FMD and 25(OH)D (r = 0.45; P = 0.001) and a negative correlation between FMD and TBARS (r = -0.28; P < 0.05) were observed. There was a significant increase in leptin levels after therapy, and the leptin levels were positively correlated with 25(OH)D levels (r = 0.45; P < 0.05). Conclusions: This study shows that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation. Replacement of vitamin D has favorable effects on endothelial function. Vitamin D deficiency can be seen as an independent risk factor of atherosclerosis. Hypovitaminosis D-associated endothelial dysfunction may predispose to higher rates of cardiovascular disease in the winter. (J Clin Endocrinol Metab 94: 4023-4030, 2009)
dc.identifier.doi10.1210/jc.2008-1212
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.pubmed19584181
dc.identifier.urihttps://hdl.handle.net/11424/242847
dc.identifier.wosWOS:000270526500053
dc.language.isoeng
dc.publisherENDOCRINE SOC
dc.relation.ispartofJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSERUM PARAOXONASE ACTIVITY
dc.subjectBEAM COMPUTED-TOMOGRAPHY
dc.subjectOXIDATIVE STRESS
dc.subjectINSULIN SENSITIVITY
dc.subjectPOSTMENOPAUSAL WOMEN
dc.subjectPARATHYROID-HORMONE
dc.subjectLIPID-PEROXIDATION
dc.subjectDIABETES-MELLITUS
dc.subjectGLUCOSE-TOLERANCE
dc.subjectHEART-DISEASE
dc.titleEffect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects
dc.typearticle
dspace.entity.typePublication
local.avesis.id314df75a-d13c-4268-850d-fe2278be8f50
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage4030
oaire.citation.issue10
oaire.citation.startPage4023
oaire.citation.titleJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
oaire.citation.volume94
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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