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The effect of metformin on ethanol- and indomethacininduced gastric ulcers in rats

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dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorCABADAK, HÜLYA
dc.contributor.authorAYDIN OMAY, BANU
dc.contributor.authorsİpek B. E. , YÜKSEL M., Cumbul A., ERCAN F., CABADAK H., AYDIN OMAY B., Alican İ.
dc.date.accessioned2022-10-07T08:14:53Z
dc.date.available2022-10-07T08:14:53Z
dc.date.issued2022-09-01
dc.description.abstractBACKGROUND: Previous studies found metformin as an effective agent to suppress oxidative stress, inflammation, and apoptosis in various inflammatory diseases. The present study investigated the effect of metformin against 2 experimental gastric injury models in rats, using macroscopical, histopathological, biochemical, and immunostaining studies. METHODS: After 24 hours of fasting, male Sprague-Dawley rats (280-400 g) (n = 8 per group) received indomethacin (80 mg/kg; indo ulcer group) or absolute ethanol (5 mL/kg; ethanol ulcer group) or vehicle orally by gavage. Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge. Ranitidine (50 mg/kg) was given orally for 3 days before indomethacin or ethanol administration as a positive control. On day 3, the animals were euthanized 6 hours after indo or 1 hour after ethanol challenge. Gastric samples were used for macroscopic scoring, histopathological examinations, and biochemical assays. Trunk blood was collected for the assessment of interleukin-1β level. RESULTS: In both ethanol ulcer and indo ulcer groups, metformin decreased the extent of gastric lesions macroscopically and microscopically, improved the high chemiluminescence levels, and the percentage of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells compared with untreated ulcer groups. Gastric blood flow analysis revealed significant increases in both metformin-treated ulcer groups compared to untreated ulcer groups. CONCLUSION: The findings of the present work demonstrated the gastroprotective effect of metformin against the development of gastric mucosal lesions induced by ethanol and indomethacin in non-diabetic, normoglycemic rats via its antioxidant and anti-apoptotic properties and partly from its ability to restore blood flow.
dc.identifier.citationİpek B. E. , YÜKSEL M., Cumbul A., ERCAN F., CABADAK H., AYDIN OMAY B., Alican İ., "The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats", The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.33, sa.9, ss.767-776, 2022
dc.identifier.doi10.5152/tjg.2022.21195
dc.identifier.endpage776
dc.identifier.issn2148-5607
dc.identifier.issue9
dc.identifier.startpage767
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138457775&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/282196
dc.identifier.volume33
dc.language.isoeng
dc.relation.ispartofThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGastroenterology and Hepatology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectGASTROENTEROLOGY & HEPATOLOGY
dc.subjectGastroenteroloji
dc.subjectGastroenterology
dc.titleThe effect of metformin on ethanol- and indomethacininduced gastric ulcers in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id93dcd3e0-05a7-44bc-aee1-6ef22671f919
local.indexed.atPUBMED
local.indexed.atSCOPUS
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