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The roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus

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dc.contributor.authorDAĞLI, EMRULLAH TOLGA
dc.contributor.authorsOzel, SK; Dagli, TE; Yuksel, M; Kiyan, G; Kotiloglu, E
dc.date.accessioned2022-03-12T17:17:12Z
dc.date.available2022-03-12T17:17:12Z
dc.date.issued2004
dc.description.abstractPurpose: The authors aimed to find out the roles of free oxygen radicals, nitric oxide (NO), and endothelin (ET) in caustic injury of rat esophagus. Methods: Forty-five Wistar albino rats were used to form 6 groups. The study groups are summarized as 1, sham (S; n = 7); 2, sham + L-arginine (SA; n 7); 3, sham + L-NAME (SN; n = 7); 4, injury (I; n = 8); 5, injury + L-arginine (IA; n = 8); 6, injury + L-NAME (IN; n = 8). Normal saline in the sham groups and 50% NaOH in the caustic injury groups were administered to the distal esophagus. Free oxygen radicals and NO were detected by chemiluminescence from tissue samples, and they were correlated with histologic examinations. Tissue ET was measured also with immunohistochemistry. Results: The injury was verified histologically. Free oxygen radical levels were found to be increased as well as NO and ET with the caustic injury (P < .05). L-arginine caused a histologic increase in the injury that was close to statistical significance (P = .08). L-NAME showed no significant effect. Conclusions: Free radicals, NO, and ET increase in the early phase of caustic esophageal injury. Understanding their early interactions during the caustic injury may help in future therapeutic strategies. (C) 2004 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jpedsurg.2004.05.014
dc.identifier.eissn1531-5037
dc.identifier.issn0022-3468
dc.identifier.pubmed15359394
dc.identifier.urihttps://hdl.handle.net/11424/227789
dc.identifier.wosWOS:000223963300014
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcaustic esophagitis
dc.subjectfree oxygen radicals
dc.subjectnitric oxide
dc.subjectendothelin
dc.subjectBURNS
dc.subjectCORTICOSTEROIDS
dc.subjectINHIBITION
dc.subjectCHILDREN
dc.subjectRELEASE
dc.subjectTRIAL
dc.titleThe roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus
dc.typearticle
dspace.entity.typePublication
local.avesis.id1b44c2e5-f602-476f-85fb-f8993724d7ee
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage1385
oaire.citation.issue9
oaire.citation.startPage1381
oaire.citation.titleJOURNAL OF PEDIATRIC SURGERY
oaire.citation.volume39
relation.isAuthorOfPublicationc7f9c4a9-8b86-46b2-aefe-03541e0f7f7c
relation.isAuthorOfPublication.latestForDiscoveryc7f9c4a9-8b86-46b2-aefe-03541e0f7f7c

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