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Preventing blood-induced joint damage with the use of intra-articular iron chelators: an experimental study in rabbits

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dc.contributor.authorEROL, BÜLENT
dc.contributor.authorsKocaoglu, Baris; Akgun, Umut; Erol, Buelent; Karahan, Mustafa; Yalcin, Selim
dc.date.accessioned2022-03-12T17:46:55Z
dc.date.available2022-03-12T17:46:55Z
dc.date.issued2009
dc.description.abstractThis animal model was designed to evaluate the effect of intra-articular iron-chelator treatment in the prevention of blood-induced joint disease. Thirty domestic male rabbits were divided into three equal groups. One milliliter of homologous blood was injected into the left knee of each rabbit in groups 1 and 2. In the second group, 0.1 ml desferroxamine mesilate (DM) was also injected to the blood. In group 3, the animals received injections of 0.1 DM which was mixed with equal amounts of sterile saline solution. The joints were injected three times each week for 12 weeks. At the end of 12 weeks, the knee joints of each rabbit were examined. The synovium in group 1 was found statistically significantly thicker than in group 2. Obvious erosion and ulceration of the cartilage were seen in all joints in group 1 and absent in group 2. Iron-chelator treatment reduced the formation of blood-induced joint damage in rabbit knees by inhibiting the iron-catalyzed formation of destructive oxygen metabolites that has an effect on joint cartilage and synovium.
dc.identifier.doi10.1007/s00402-009-0885-x
dc.identifier.eissn1434-3916
dc.identifier.issn0936-8051
dc.identifier.pubmed19437025
dc.identifier.urihttps://hdl.handle.net/11424/229603
dc.identifier.wosWOS:000270427000019
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood
dc.subjectCartilage damage
dc.subjectOxidative stress
dc.subjectIron chelator
dc.subjectHEMOPHILIC SYNOVITIS
dc.subjectIN-VITRO
dc.subjectMODEL
dc.subjectTHERAPY
dc.titlePreventing blood-induced joint damage with the use of intra-articular iron chelators: an experimental study in rabbits
dc.typearticle
dspace.entity.typePublication
local.avesis.id888d7e43-7243-43cf-8343-722e900f90c1
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages5
oaire.citation.endPage1575
oaire.citation.issue11
oaire.citation.startPage1571
oaire.citation.titleARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
oaire.citation.volume129
relation.isAuthorOfPublicatione87cb1cd-69ae-4a92-893b-901e999c9240
relation.isAuthorOfPublication.latestForDiscoverye87cb1cd-69ae-4a92-893b-901e999c9240

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