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Effects of restoration of the euthyroid state on epicardial adipose tissue and carotid intima media thickness in subclinical hypothyroid patients

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dc.contributor.authorÖZBEN SADIÇ, BESTE
dc.contributor.authorsYazici, Dilek; Ozben, Beste; Toprak, Ahmet; Yavuz, Dilek; Aydin, Hasan; Tarcin, Ozlem; Deyneli, Oguzhan; Akalin, Sema
dc.date.accessioned2022-03-12T20:26:46Z
dc.date.available2022-03-12T20:26:46Z
dc.date.issued2015
dc.description.abstractEpicardial adipose tissue (EAT) thickness is a novel cardiovascular risk indicator, whereas carotid intima media thickness (CIMT) is a known marker of subclinical atherosclerosis. The aim of this study was to measure EAT thickness and CIMT in subclinical hypothyroid (SCH) patients and to determine the effect of restoration of the euthyroid state on these variables. The study included 43 patients with SCH (mean age: 35.2 +/- 10.7 years; F-M ratio: 42: 1) and 30 healthy controls (mean age: 34.5 +/- 8.2 years; F-M ratio: 25: 5). EAT thickness and CIMT were measured via conventional echocardiography and ultrasonography. Among the patients, 23 were followed up with L-thyroxine replacement until restoration of the euthyroid state and re-evaluated 6 months after baseline. Basal EAT thickness was higher in the SCH patients than in the controls (3.2 +/- 0.7 vs. 2.3 +/- 0.3 mm-p < 0.0001), whereas CIMT was similar in both groups (0.50 +/- 0.09 vs. 0.48 +/- 0.04 mm). EAT thickness was correlated with CIMT in the patient group (r = 0.39, p = 0.01), but this correlation was not evident based on multivariate analysis when corrected for age and body mass index (r(2) = 0.47 and p = 0.0001 for the model). In the follow-up patient subgroup, both EAT thickness and CIMT decreased significantly following L-thyroxine treatment, when normal TSH levels were attained (3.4 +/- 0.7 vs. 2.3 +/- 0.5 mm-p = 0.007 and 0.51 +/- 0.09 vs. 0.46 +/- 0.07 mm-p = 0.01, respectively). EAT thickness was greater in the SCH patients than in controls, whereas CIMT was similar in both groups. Restoration of the euthyroid state with L-thyroxine treatment was associated with significant decreases in EAT thickness and CIMT in the group of patients that received L-thyroxine treatment and, as such, might reduce the cardiovascular risk associated with SCH.
dc.identifier.doi10.1007/s12020-014-0372-1
dc.identifier.eissn1559-0100
dc.identifier.issn1355-008X
dc.identifier.pubmed25108389
dc.identifier.urihttps://hdl.handle.net/11424/233555
dc.identifier.wosWOS:000351661100023
dc.language.isoeng
dc.publisherHUMANA PRESS INC
dc.relation.ispartofENDOCRINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpicardial adipose tissue thickness
dc.subjectCarotid intima media thickness
dc.subjectSubclinical hypothyroidism
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectVASCULAR SMOOTH-MUSCLE
dc.subjectMETABOLIC SYNDROME
dc.subjectTHYROID-FUNCTION
dc.subjectRISK-FACTOR
dc.subjectINDEPENDENT PREDICTOR
dc.subjectCLINICAL-SIGNIFICANCE
dc.subjectCARDIOVASCULAR RISK
dc.subjectFREE-THYROXINE
dc.subjectHEART-DISEASE
dc.titleEffects of restoration of the euthyroid state on epicardial adipose tissue and carotid intima media thickness in subclinical hypothyroid patients
dc.typearticle
dspace.entity.typePublication
local.avesis.ida5eace26-44b9-46e0-9b3a-57ac5ad4475e
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage915
oaire.citation.issue3
oaire.citation.startPage909
oaire.citation.titleENDOCRINE
oaire.citation.volume48
relation.isAuthorOfPublicationa3b8b4a2-fc05-4f42-b6ec-5a452471f501
relation.isAuthorOfPublication.latestForDiscoverya3b8b4a2-fc05-4f42-b6ec-5a452471f501

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