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Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson's Disease

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsSaylam, Ezgi; Akkaya, Yigit; Ilhan, Elif; Cesur, Sumeyye; Guler, Ece; Sahin, Ali; Cam, Muhammmet Emin; Ekren, Nazmi; Oktar, Faik Nuzhet; Gunduz, Oguzhan; Ficai, Denisa; Ficai, Anton
dc.date.accessioned2022-03-14T09:56:39Z
dc.date.available2022-03-14T09:56:39Z
dc.date.issued2021-11-13
dc.description.abstractParkinson's disease, the second most common neurodegenerative disease in the world, develops due to decreased dopamine levels in the basal ganglia. Levodopa, a dopamine precursor used in the treatment of Parkinson's disease, can be used as a drug delivery system. This study presents an approach to the use of 3D-printed levodopa-loaded neural tissue scaffolds produced with polylactic acid (PLA) and chitosan (CS) for the treatment of Parkinson's disease. Surface morphology and pore sizes were examined by scanning electron microscopy (SEM). Average pore sizes of 100-200 mu m were found to be ideal for tissue engineering scaffolds, allowing cell penetration but not drastically altering the mechanical properties. It was observed that the swelling and weight loss behaviors of the scaffolds increased after the addition of CS to the PLA. Levodopa was released from the 3D-printed scaffolds in a controlled manner for 14 days, according to a Fickian diffusion mechanism. Mesenchymal stem cells (hAD-MSCs) derived from human adipose tissue were used in MTT analysis, fluorescence microscopy and SEM studies and confirmed adequate biocompatibility. Overall, the obtained results show that PLA/CS 3D-printed scaffolds have an alternative use for the levodopa delivery system for Parkinson's disease in neural tissue engineering applications.
dc.identifier.doi10.3390/app112210727
dc.identifier.eissn2076-3417
dc.identifier.urihttps://hdl.handle.net/11424/243730
dc.identifier.wosWOS:000725094700001
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofAPPLIED SCIENCES-BASEL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlevodopa
dc.subjectParkinson's disease
dc.subject3D-printed scaffold
dc.subjectbiomaterials
dc.subjecttissue engineering
dc.subjectdrug delivery
dc.subjectCONTROLLED-RELEASE
dc.subjectCHITOSAN
dc.subjectFUNCTIONALIZATION
dc.subjectNANOPARTICLES
dc.subjectFABRICATION
dc.subjectBEHAVIOR
dc.titleLevodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson's Disease
dc.typearticle
dspace.entity.typePublication
local.avesis.iddc7acb4b-87ff-4ee6-8aaf-ca3679b2f698
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber10727
local.journal.numberofpages21
oaire.citation.issue22
oaire.citation.titleAPPLIED SCIENCES-BASEL
oaire.citation.volume11
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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