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Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsDepciuch J., Jakubczyk P., Paja W., Sarzyński J., Pancerz K., AÇIKEL ELMAS M., Keskinöz E., BİNGÖL ÖZAKPINAR Ö., ARBAK S., Özgün G., et al.
dc.date.accessioned2023-07-25T08:28:09Z
dc.date.available2023-07-25T08:28:09Z
dc.date.issued2022-10-15
dc.description.abstract© 2022 Elsevier B.V.Herein, we examined the modulatory effects of Apocynum (APO) on Monosodium Glutamate (MSG)-induced oxidative damage on the brain tissue of rats after long-term consumption of blood serum components by biochemical assays, Fourier transform infrared spectroscopy (FTIR), and machine learning methods. Sprague-Dawley male rats were randomly divided into the Control, Control + APO, MSG, and MSG + APO groups (n = 8 per group). All administrations were made by oral gavage saline, MSG, or APO and they were repeated for 28 days of the experiments. Brain tissue and blood serum samples were collected and analyzed for measurement levels of malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), superoxide dismutase (SOD) activity, and Spectroscopic analysis. After 29 days, the results were evaluated using machine learning (ML). The levels of MDA and MPO showed changes in the MSG and MSG + APO groups, respectively. Changes in the proteins and lipids were observed in the FTIR spectra of the MSG groups. Additionally, APO in these animals improved the FTIR spectra to be similar to those in the Control group. The accuracy of the FTIR results calculated by ML was 100%. The findings of this study demonstrate that Apocynin treatment protects against MSG-induced oxidative damage by inhibiting reactive oxygen species and upregulating antioxidant capacity, indicating its potential in alleviating the toxic effects of MSG.
dc.identifier.citationDepciuch J., Jakubczyk P., Paja W., Sarzyński J., Pancerz K., AÇIKEL ELMAS M., Keskinöz E., BİNGÖL ÖZAKPINAR Ö., ARBAK S., Özgün G., et al., "Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study", Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, cilt.279, 2022
dc.identifier.doi10.1016/j.saa.2022.121495
dc.identifier.issn1386-1425
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131796852&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/291539
dc.identifier.volume279
dc.language.isoeng
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFizik
dc.subjectAtom ve Molekül Fiziği
dc.subjectKimya
dc.subjectAnalitik Kimya
dc.subjectFizikokimya
dc.subjectSpektroskopi
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectPhysics
dc.subjectAtomic and Molecular Physics
dc.subjectChemistry
dc.subjectAnalytical Chemistry
dc.subjectPhysical Chemistry
dc.subjectSpectroscopy
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectALETLER & GÖSTERİM
dc.subjectKİMYA, ANALİTİK
dc.subjectSPEKTROSKOPİ
dc.subjectFİZİK, ATOMİK, MOLEKÜLER VE KİMYASAL
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectCHEMISTRY
dc.subjectPHYSICS
dc.subjectINSTRUMENTS & INSTRUMENTATION
dc.subjectCHEMISTRY, ANALYTICAL
dc.subjectSPECTROSCOPY
dc.subjectPHYSICS, ATOMIC, MOLECULAR & CHEMICAL
dc.subjectFizik Bilimleri
dc.subjectAtom ve Moleküler Fizik ve Optik
dc.subjectEnstrümantasyon
dc.subjectPhysical Sciences
dc.subjectAtomic and Molecular Physics, and Optics
dc.subjectInstrumentation
dc.subjectMonosodium glutamate
dc.subjectApocynin
dc.subjectBrain tissue
dc.subjectOxidative load
dc.subjectFTIR
dc.subjectMachine learning
dc.subjectSECONDARY STRUCTURE
dc.subjectHYPERTENSIVE-RATS
dc.subjectAGONISTS
dc.subjectSTRESS
dc.subjectDAMAGE
dc.subjectASSAY
dc.subjectBURST
dc.titleApocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e102085-69ed-4e44-8111-39bae44070d0
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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