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Challenges in the management of a 7 years old child with thyrotropin-secreting pituitary adenoma and the review of the literature

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dc.contributor.authorKIRKGÖZ, TARIK
dc.contributor.authorGÜRPINAR TOSUN, BUŞRA
dc.contributor.authorELTAN, MEHMET
dc.contributor.authorHALİLOĞLU, BELMA
dc.contributor.authorKAYGUSUZ, SARE BETÜL
dc.contributor.authorSEVEN MENEVŞE, TUBA
dc.contributor.authorBOZKURT, SÜHEYLA
dc.contributor.authorÖNEŞ, TUNÇ
dc.contributor.authorGÜRAN, TÜLAY
dc.contributor.authorDAĞÇINAR, ADNAN
dc.contributor.authorBEREKET, ABDULLAH
dc.contributor.authorDEMİRCİOĞLU, SERAP
dc.contributor.authorsKIRKGÖZ T., Abali S., Seker A., GÜRPINAR TOSUN B., ELTAN M., Helvacioglu D., HALİLOĞLU B., KAYGUSUZ S. B., Yavas Abali Z., SEVEN MENEVŞE T., et al.
dc.date.accessioned2023-02-27T13:12:57Z
dc.date.available2023-02-27T13:12:57Z
dc.date.issued2023-01-01
dc.description.abstractIntroduction: Thyrotropin-producing pituitary adenoma (TSHoma) is a very rare disease, representing less than 1% of the pituitary tumours, present with elevated thyroid hormones and normal/high TSH concentrations. Case Presentation: A 7-year-old boy with nervousness was referred by his psychiatrist for elevated free T4, T3 and TSH levels. Initial evaluation revealed an elevated -subunit.Pituitary MRI demonstrated a macroadenoma. The patient underwent a trans-sphenoidal tumour resection (TSS) which showed positive immunohistochemical staining for TSH, growth hormone, and prolactin in tumoral tissue. Euthyroidism was achieved for one year after TSS, then, recurrence of tumour with elevated TSH and thyroid hormone levels necessitated a re-operation with TSS followed by gamma-knife radiosurgery. The euthyroid state was achieved and lasted for 2.5 years this time, but, due to the recurrence, medical treatment had been commenced with cabergoline and octreotide. Euthyroidism was maintained for the last 4 years on monthly octreotide treatment. A repeat MRI demonstrated no pituitary mass but a mass in the sphenoidal sinus had been detected. Removal of this mass by surgery did not achieve euthyroidism. 68Ga-DOTA-TATE PET/CT showed residual tissue extending from the pituitary region to the sphenoid sinus.The patient\"s bone age was advanced 2 years at diagnosis which became 4 years in one year after the diagnosis and remained so throughout follow-up, leading to a final height of -3.3 SDS below his target height at the age of 16 years. Conclusion: The diagnosis, treatment, and follow-up of TSHomas are challenging and short stature due to accelerated bone maturation is a complication of paediatric TSHomas.
dc.identifier.citationKIRKGÖZ T., Abali S., Seker A., GÜRPINAR TOSUN B., ELTAN M., Helvacioglu D., HALİLOĞLU B., KAYGUSUZ S. B., Yavas Abali Z., SEVEN MENEVŞE T., et al., "Challenges in the management of a 7 years old child with thyrotropin-secreting pituitary adenoma and the review of the literature", HORMONE RESEARCH IN PAEDIATRICS, 2023
dc.identifier.doi10.1159/000529070
dc.identifier.issn1663-2818
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/36630941/
dc.identifier.urihttps://hdl.handle.net/11424/286858
dc.language.isoeng
dc.relation.ispartofHORMONE RESEARCH IN PAEDIATRICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectHealth Sciences
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPEDİATRİ
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPEDIATRICS
dc.subjectPediatri
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectPediatrics
dc.subjectEndocrine and Autonomic Systems
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectLife Sciences
dc.titleChallenges in the management of a 7 years old child with thyrotropin-secreting pituitary adenoma and the review of the literature
dc.typearticle
dspace.entity.typePublication
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local.indexed.atWOS
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