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Health-related quality of life in patients with bronchiolitis obliterans

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsAtag, Emine; Ikizoglu, Nilay Bas; Ergenekon, Pinar; Kalin, Sevinc; Unal, Fusun; Gokdemir, Yasemin; Eralp, Ela Erdem; Yalcin, Koray; Oktem, Sedat; Ersu, Refika; Karakoc, Fazilet; Karadag, Bulent
dc.date.accessioned2022-03-12T22:54:49Z
dc.date.available2022-03-12T22:54:49Z
dc.date.issued2020
dc.description.abstractIntroduction Bronchiolitis obliterans (BO) is mainly caused by infections and hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the health-related quality of life (HRQOL) of children with BO compared to the healthy children and also to assess the HRQOL according to the etiology. Methods Postinfectious (group 1) and post-HSCT BO (group 2) patients and healthy children were included in the study. HRQOL was assessed by the Short Form-36 (SF-36) and St George's Respiratory Questionnaire (SGRQ). Correlations between demographic and clinical characteristics, pulmonary function tests, high-resolution chest tomography scores, and HRQOL were assessed. Results Thirty-seven postinfectious and post-HSCT BO patients and 34 healthy children were included in the study. Mean age was 13.8 +/- 0.7 years. Mean forced vital capacity and forced expiratory volume(1)were 60.7 +/- 2.7% predicted, and 49.8 +/- 3.1% predicted, respectively. The SF-36 scores were lower in BO patients compared to healthy children (P < .01). Patients with better lung functions had higher SF-36 scores, but lower SGRQ. The number of inhaled therapies, acute exacerbations, hospitalizations were inversely correlated with SF-36. A positive correlation was found between these parameters and total SGRQ scores (r = .507,P = .02;r = .409,P = .12;r = .326,P = .049, respectively). SF-36 scores were better in group 1 for subscales of physical role functioning and social role functioning compared to group 2. (P = .01,P = .01, respectively). Conclusion The HRQOL of patients with BO measured by SF-36 was low compared to healthy children. SF-36 scores were more affected in post-HSCT BO patients. HRQOL of children with chronic lung disease should be taken into consideration in the management of these patients.
dc.identifier.doi10.1002/ppul.24896
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.pubmed32515559
dc.identifier.urihttps://hdl.handle.net/11424/236537
dc.identifier.wosWOS:000540213000001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPEDIATRIC PULMONOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbronchiolitis obliterans
dc.subjectchildren
dc.subjectquality of life
dc.subjectVERSUS-HOST-DISEASE
dc.subjectCYSTIC-FIBROSIS
dc.subjectCELL TRANSPLANTATION
dc.subjectCHILDREN
dc.titleHealth-related quality of life in patients with bronchiolitis obliterans
dc.typearticle
dspace.entity.typePublication
local.avesis.idc6ec9383-50a9-410d-af9d-09fecac2beeb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage2367
oaire.citation.issue9
oaire.citation.startPage2361
oaire.citation.titlePEDIATRIC PULMONOLOGY
oaire.citation.volume55
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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