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The physiology of learning and memory: Role of peptides and stress

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsGulpinar, MA; Yegen, BC
dc.date.accessioned2022-03-10T15:24:57Z
dc.date.available2022-03-10T15:24:57Z
dc.date.issued2004
dc.description.abstractThe neuropeptides, as well as their respective receptors, are widely distributed throughout the mammalian central nervous system. During learning and memory processes, besides structural synaptic remodeling, changes are observed at molecular and metabolic levels with the alterations in neurotransmitter and neuropeptide synthesis and release. While there is consensus that brain cholinergic neurotransmission plays a critical role in the processes related to learning and memory, it is also well known that these functions are influenced by a tremendous number of neuropeptides and non-peptide molecules. Arginine vasopressin (AVP), oxytocin, angiotensin II, insulin, growth factors, serotonin (5-HT), melanin concentrating hormone, histamine, bombesin and gastrin-re leasing peptide (GRP), glucagon-like peptide-1 (GLP-1). cholecystokinin (CCK), dopamine, corticotropin releasing factor (CRT) have modulatory effects on learning and memory. Among these peptides CCK, 5-HT and CRF play strategic roles in the modulation of memory processes under stressful conditions. CRF is accepted as the main neuropeptide involved in both physical and emotional stress.. with a protective role during stress, possibly through the activation of the hypothalamo-pitiuitary (HPA) axis. The peptide CCK has been proposed to facilitate memory processing and CCK-like immunoreactivity in the hypothalamus was observed upon stress exposure, suggesting that CCK may participate in the central control of stress response and stress-induced memory dysfunction. On the other hand, 5-HT appears to play a role in behaviors that involve a high cognitive demand and stress exposure activates serotonergic systems in a variety of brain regions. The physiological role and therapeutic efficacy of various neuropeptides and the impact of stress exposure in the acquisition and consolidation of memory will be reviewed thoroughly.
dc.identifier.doi10.2174/1389203043379341
dc.identifier.eissn1875-5550
dc.identifier.issn1389-2037
dc.identifier.pubmed15581416
dc.identifier.urihttps://hdl.handle.net/11424/220026
dc.identifier.wosWOS:000224902600003
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PROTEIN & PEPTIDE SCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer's disease (AD)
dc.subjectacquisition
dc.subjectconsolidation
dc.subjectstress
dc.subjectsocial memory
dc.subjectserotonin (5-HT)
dc.subjectcholecystokinin (CCK)
dc.subjectcorticotropin releasing factor (CRF)
dc.subjecthypothalomo-pitiutary (HPA) axis
dc.subjectCORTICOTROPIN-RELEASING-FACTOR
dc.subjectCELL-ADHESION MOLECULE
dc.subjectLONG-TERM POTENTIATION
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectPASSIVE-AVOIDANCE TASK
dc.subjectMORRIS WATER MAZE
dc.subjectFACTOR (CRF)-LIKE IMMUNOREACTIVITY
dc.subjectHIPPOCAMPAL CA3C NEURONS
dc.subjectCHRONIC RESTRAINT STRESS
dc.subjectCENTRAL 5-HT4 RECEPTORS
dc.titleThe physiology of learning and memory: Role of peptides and stress
dc.typereview
dspace.entity.typePublication
local.avesis.id34f8f999-3dbb-45ca-a7f2-7e6e36faece4
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages17
oaire.citation.endPage473
oaire.citation.issue6
oaire.citation.startPage457
oaire.citation.titleCURRENT PROTEIN & PEPTIDE SCIENCE
oaire.citation.volume5
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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