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Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsOzcan Bulbul E., Ustundag Okur N., Misirli D., Cevher E., Tsanaktsis V., BİNGÖL ÖZAKPINAR Ö., Siafaka P. I.
dc.date.accessioned2023-05-08T07:19:37Z
dc.date.available2023-05-08T07:19:37Z
dc.date.issued2022-04-01
dc.description.abstractIn the present study, poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu) or poly(ethylene glycol) (PEG) under the framework of quality by design, were blended to produce effective sustained-release matrices for Paclitaxel delivery. A complete physicochemical characterization including weight variation, thickness, water uptake, moisture absorption, moisture loss, and hydrolytic degradation under physiological conditions, was performed. Quality by design approach was applied to study the critical parameters. In vitro cancer toxicity was studied in human cancer cell lines including lung and breast adenocarcinoma. The developed Paclitaxel-loaded films can act as a promising alternative topical matrix as an implant for breast and lung cancer treatment.
dc.identifier.citationOzcan Bulbul E., Ustundag Okur N., Misirli D., Cevher E., Tsanaktsis V., BİNGÖL ÖZAKPINAR Ö., Siafaka P. I., "Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery", INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022
dc.identifier.doi10.1080/00914037.2022.2067538
dc.identifier.issn0091-4037
dc.identifier.urihttps://hdl.handle.net/11424/289128
dc.language.isoeng
dc.relation.ispartofINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemistry
dc.subjectPhysical Chemistry
dc.subjectCharacterization of Polymers
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectPOLİMER BİLİMİ
dc.subjectTemel Bilimler (SCI)
dc.subjectMATERIALS SCIENCE, BIOMATERIALS
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectPOLYMER SCIENCE
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectBiyomalzemeler
dc.subjectMalzeme Bilimi (çeşitli)
dc.subjectPolimerler ve Plastikler
dc.subjectKimya (çeşitli)
dc.subjectGenel Malzeme Bilimi
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectBiomaterials
dc.subjectMaterials Science (miscellaneous)
dc.subjectPolymers and Plastics
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Materials Science
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectBreast cancer
dc.subjectcancer treatment
dc.subjectfilm
dc.subjectlung cancer
dc.subjectpaclitaxel
dc.subjectquality by design
dc.subjectCONTROLLED-RELEASE FORMULATIONS
dc.subjectIN-VITRO
dc.subjectPOLY(ETHYLENE SUCCINATE)
dc.subjectBLENDS
dc.subjectNANOPARTICLES
dc.subjectFILMS
dc.subjectSYSTEM
dc.subjectCRYSTALLIZATION
dc.subjectBIOAVAILABILITY
dc.subjectPLASTICIZERS
dc.titleApplying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery
dc.typearticle
dspace.entity.typePublication
local.avesis.id6c758bc7-e630-4991-9465-dcf834c520ee
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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