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2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis

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dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsRobson J. C., Grayson P. C., Ponte C., Craven A., Judge A., Khalid S., Hutchings A., Watts R. A., Merkel P. A., Luqmani R. A., et al.
dc.date.accessioned2023-11-20T08:28:47Z
dc.date.available2023-11-20T08:28:47Z
dc.date.issued2022-03-01
dc.description.abstractObjective: To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate criteria items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data-driven reduction of the number of candidate items, 4) expert panel review of cases to define the reference diagnosis, and 5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators. Results: The development set for GPA consisted of 578 cases of GPA and 652 comparators. The validation set consisted of an additional 146 cases of GPA and 161 comparators. From 91 candidate items, regression analysis identified 26 items for GPA, 10 of which were retained. The final criteria and their weights were as follows: bloody nasal discharge, nasal crusting, or sino-nasal congestion (+3); cartilaginous involvement (+2); conductive or sensorineural hearing loss (+1); cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti–proteinase 3 ANCA positivity (+5); pulmonary nodules, mass, or cavitation on chest imaging (+2); granuloma or giant cells on biopsy (+2); inflammation or consolidation of the nasal/paranasal sinuses on imaging (+1); pauci-immune glomerulonephritis (+1); perinuclear ANCA or antimyeloperoxidase ANCA positivity (−1); and eosinophil count ≥1 × 109/liter (−4). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having GPA if the cumulative score was ≥5 points. When these criteria were tested in the validation data set, the sensitivity was 93% (95% confidence interval [95% CI] 87–96%) and the specificity was 94% (95% CI 89–97%). Conclusion: The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for GPA demonstrate strong performance characteristics and are validated for use in research.
dc.identifier.citationRobson J. C., Grayson P. C., Ponte C., Craven A., Judge A., Khalid S., Hutchings A., Watts R. A., Merkel P. A., Luqmani R. A., et al., "2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis", Arthritis and Rheumatology, cilt.74, sa.3, ss.393-399, 2022
dc.identifier.doi10.1002/art.41986
dc.identifier.endpage399
dc.identifier.issn2326-5191
dc.identifier.issue3
dc.identifier.startpage393
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/1d0d1025-2f32-4ae7-b77a-555afef9d369/file
dc.identifier.urihttps://hdl.handle.net/11424/294970
dc.identifier.volume74
dc.relation.ispartofArthritis and Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectİmmünoloji
dc.subjectALERJİ
dc.subjectROMATOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectIMMUNOLOGY
dc.subjectALLERGY
dc.subjectRHEUMATOLOGY
dc.subjectİmmünoloji ve Alerji
dc.subjectRomatoloji
dc.subjectImmunology and Allergy
dc.subjectRheumatology
dc.subjectImmunology
dc.title2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Granulomatosis With Polyangiitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id1d0d1025-2f32-4ae7-b77a-555afef9d369
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationd63c059c-cb70-4f22-b278-5eafbbbe7e25
relation.isAuthorOfPublication.latestForDiscoveryd63c059c-cb70-4f22-b278-5eafbbbe7e25

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