Publication:
Exercise and caloric restriction improve cardiovascular and erectile function in rats with metabolic syndrome

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dc.contributor.authorŞENER, TARIK EMRE
dc.contributor.authorŞENER, GÖKSEL
dc.contributor.authorsÇevikelli Yakut Z. A., Özçelik R., Çevik Ö., Şener T. E., Şener G.
dc.date.accessioned2023-08-09T12:20:30Z
dc.date.available2023-08-09T12:20:30Z
dc.date.issued2020-12-01
dc.description.abstractThe aim of this study is to examine the possible benefits of exercise and caloric restriction (CR) on cardiovascular hemodynamics, erectile function, and antioxidant system in metabolic syndrome (MS). Sixty male Spraque-Dawley rats were divided into five groups; control, MS, MS + CR, MS + exercise (EXC), and MS + CR + EXC. To induce MS, 10% fructose solution was applied for 3 months. Thereafter, in CR groups calorie was restricted 40% and in EXC groups swimming was performed for 6 weeks. Body weight, blood glucose, and blood pressure (BP) levels were measured before and after MS induction and at the end of the experiment. After decapitation, tumor necrosis factor (TNF)-α, adiponectin (ADP), and plasminogen activator inhibitor (PAI)-1 levels were investigated in blood, oxidative stress parameters were examined in heart, aorta, and corpus cavernosum (CC) tissues. Isometric contraction in isolated tissue bath was studied in aorta and CC tissues. Animals subjected to exercise and CR had decreased BP and blood glucose levels. Impaired contraction-relaxation responses in MS group were improved with exercise and CR. MS-induced increase in TNF-α, PAI-1, malondialdehyde (MDA), and decrease in ADP, glutathione (GSH), and superoxide dismutase (SOD) were normalized with exercise and CR. Exercise and CR may be beneficial against changes in cardiovascular hemodynamics caused by MS.
dc.identifier.citationÇevikelli Yakut Z. A., Özçelik R., Çevik Ö., Şener T. E., Şener G., "Exercise and caloric restriction improve cardiovascular and erectile function in rats with metabolic syndrome", INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, cilt.33, sa.8, ss.844-853, 2020
dc.identifier.endpage853
dc.identifier.issn0955-9930
dc.identifier.issue8
dc.identifier.startpage844
dc.identifier.urihttps://www.nature.com/articles/s41443-020-00356-w
dc.identifier.urihttps://hdl.handle.net/11424/292195
dc.identifier.volume33
dc.language.isoeng
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectÜroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectUrology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectCERRAHİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectUROLOGY & NEPHROLOGY
dc.subjectSURGERY
dc.subjectCerrahi
dc.subjectNefroloji
dc.subjectSurgery
dc.subjectNephrology
dc.titleExercise and caloric restriction improve cardiovascular and erectile function in rats with metabolic syndrome
dc.typearticle
dspace.entity.typePublication
local.avesis.id109b92c4-226b-4d1b-a5a3-0076f3e25e05
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
relation.isAuthorOfPublication5ff4af68-b410-4de6-be8b-a4a80167107e
relation.isAuthorOfPublication2fd85a89-446e-49e1-98c9-d20b11a1a2b5
relation.isAuthorOfPublication.latestForDiscovery5ff4af68-b410-4de6-be8b-a4a80167107e

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