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Neuroprotective Effect of Erythropoietin on PhenylhydrazineInduced Hemolytic Hyperbilirubinemia in Neonatal Rats

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dc.contributor.authorMEMİŞOĞLU, ASLI
dc.contributor.authorsMemisoglu, Asli; Kolgazi, Meltem; Yaman, Akan; Bahadir, Elif; Sirvanci, Serap; Yegen, Berrak C.; Ozek, Eren
dc.date.accessioned2022-03-12T22:23:38Z
dc.date.available2022-03-12T22:23:38Z
dc.date.issued2017
dc.description.abstractNeonatal unconjugated hyperbilirubinemia might cause severe bilirubin neurotoxicity in especially hemolytic conditions. The study aimed to elucidate the potential neuroprotective effects of erythropoietin (EPO) in hemolysis-induced hyperbilirubinemia. In newborn rats, hyperbilirubinemia secondary to hemolysis was induced by injecting with phenylhydrazine hydrochloride (PHZ) and rats were injected with either vehicle or EPO. At 54th hour of the PHZ injection, rats were decapitated. Serum levels of TNF-alpha, IL-1 beta, IL-10, brain-derived neurotrophic factor (BDNF) and S100-B and brain malondialdehyde, glutathione levels and myeloperoxidase activities were measured. TUNEL staining and NF-kappa B expression were evaluated. As compared to control pups, in vehicle-treated PHZ group, TNF-alpha and IL- 1 beta levels, malondialdehyde level and myeloperoxidase activity were increased with concomitant decreases in IL-10 and glutathione. All EPO regimens reversed PHZ-induced alterations in IL-10, TNFa, malondialdehyde and glutathione levels. Three-daytreatment abolished increases in myeloperoxidase activity and IL-1 beta levels, while BDNF and S100-B were elevated. Increased TUNEL (+) cells and NF-kappa B expressions in the brain of PHZ group were reduced in the 3-day-treated group. EPO exerted anti- inflammatory effects on PHZinduced neural damage in newborn rats, while the neuroprotection was more obvious when the treatments were repeated successively. The results suggest that EPO treatment may have a therapeutic potential in supporting neuroplasticity in the hyperbilirubinemic neonates.
dc.identifier.doi10.1007/s11064-016-2135-2
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.pubmed27995496
dc.identifier.urihttps://hdl.handle.net/11424/234491
dc.identifier.wosWOS:000398350100010
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofNEUROCHEMICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeonate
dc.subjectHyperbilirubinemia
dc.subjectHemolysis
dc.subjectNeuroprotective
dc.subjectErythropoietin
dc.subjectDOSE RECOMBINANT ERYTHROPOIETIN
dc.subjectTRAUMATIC BRAIN-INJURY
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectUNCONJUGATED BILIRUBIN
dc.subjectCYTOKINE PRODUCTION
dc.subjectHYPOXIA-ISCHEMIA
dc.subjectNERVOUS-SYSTEM
dc.subjectGLUTATHIONE-PEROXIDASE
dc.subjectINDUCED NEUROTOXICITY
dc.subjectLIPID-PEROXIDATION
dc.titleNeuroprotective Effect of Erythropoietin on PhenylhydrazineInduced Hemolytic Hyperbilirubinemia in Neonatal Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ida7f81fc6-6be8-49e5-a586-2b807c958ae0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages12
local.journal.quartileQ3
oaire.citation.endPage1037
oaire.citation.issue4
oaire.citation.startPage1026
oaire.citation.titleNEUROCHEMICAL RESEARCH
oaire.citation.volume42
relation.isAuthorOfPublication07e1109e-fb94-43fc-be87-3de70231471d
relation.isAuthorOfPublication.latestForDiscovery07e1109e-fb94-43fc-be87-3de70231471d

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