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The initial resuscitation of septic shock

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dc.contributor.authorGÜL, FETHİ
dc.contributor.authorsCinel, Ismail; Kasapoglu, Umut S.; Gul, Fethi; Dellinger, R. Phillip
dc.date.accessioned2022-03-10T15:25:40Z
dc.date.available2022-03-10T15:25:40Z
dc.date.issued2020
dc.description.abstractSeptic shock is the most severe form of sepsis, characterized by (a) persistent hypotension despite fluid resuscitation and (b) the presence of tissue hypoperfusion. Delays in the diagnosis and initiation of treatment of septic shock is associated with increasing risk for mortality. Early and effective fluid resuscitation and vasopressor administration play a crucial role in maintaining tissue perfusion in septic shock patients. A low diastolic arterial pressure (DAP) correlates with severity of arteriolar vasodilation, compromises left ventricle oxygen supply and can be used for identifying septic shock patients thatwould potentially benefit fromearlier vasopressor therapy. Controversy currently exists as to the balance of fluids and vasopressors to maintain target mean arterial pressure. The aim of this article is to review the rationale for fluid resuscitation and vasopressor therapy and the importance of both mean and diastolic blood pressure during the initial resuscitation of the septic shock. We relate our personal prescription of balancing fluids and vasopressors in the resuscitation of septic shock. (c) 2020 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jcrc.2020.02.004
dc.identifier.eissn1557-8615
dc.identifier.issn0883-9441
dc.identifier.pubmed32135409
dc.identifier.urihttps://hdl.handle.net/11424/220324
dc.identifier.wosWOS:000536499000016
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofJOURNAL OF CRITICAL CARE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSepsis
dc.subjectSeptic shock
dc.subjectVasopressors
dc.subjectFluid resuscitation
dc.subjectDiastolic blood pressure
dc.subjectMean arterial pressure
dc.subjectGOAL-DIRECTED THERAPY
dc.subjectINTERNATIONAL CONSENSUS DEFINITIONS
dc.subjectTRIAL SEQUENTIAL-ANALYSIS
dc.subjectCRITICALLY-ILL PATIENTS
dc.subjectSEVERE SEPSIS
dc.subjectFLUID RESUSCITATION
dc.subjectCRITICAL ILLNESS
dc.subjectBLOOD-PRESSURE
dc.subjectVENOUS RETURN
dc.subjectNOREPINEPHRINE
dc.titleThe initial resuscitation of septic shock
dc.typereview
dspace.entity.typePublication
local.avesis.id9e3b44c0-8524-4d1b-ac2c-1492e68f6c75
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ2
oaire.citation.endPage117
oaire.citation.startPage108
oaire.citation.titleJOURNAL OF CRITICAL CARE
oaire.citation.volume57
relation.isAuthorOfPublication907a6efd-2877-4832-b6a2-d87a28e52165
relation.isAuthorOfPublication.latestForDiscovery907a6efd-2877-4832-b6a2-d87a28e52165

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