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Vascular Behcet's disease: a comparative study from Turkey and France

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dc.contributor.authorALİBAZ ÖNER, FATMA
dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsAlibaz-Oner F., Vautier M., Aksoy A., Mirouse A., Le Joncour A., Cacoub P., Ilgin C., Saadoun D., DİRESKENELİ R. H.
dc.date.accessioned2022-12-26T14:24:22Z
dc.date.available2022-12-26T14:24:22Z
dc.date.issued2022-08-01
dc.description.abstractObjective Vascular Behcet\"s disease (VBD) is a systemic vasculitis involving both arterial and venous vessels of all sizes and occurring in up to 40% of patients with BD. VBD is the main cause of mortality in BD. Although commonly seen around the Mediterranean region, comparative studies in VBD are lacking. We aimed to compare the course and therapeutic approaches of VBD in two large cohorts from Turkey and France. Methods We included 291 VBD patients (female/male:63/228, mean age: 41.2 +/- 11.3 years) who were followed up in the Department of Internal Medicine and Clinical Immunology at Pitie-Salpetriere Hospital, Sorbonne University, Paris, France (n=131) and Rheumatology Division of Marmara University School of Medicine, Istanbul, Turkey (n=160). All clinical and demographical data were acquired from patient charts retrospectively. Results Smoking, family history for BD, HLA-B*51 presence and pathergy positivity were significantly higher in Turkish patients (TR), while neurologic involvement was more prominent in the French (FR) group. After a median follow-up of 77 months, 562 vascular events occurred including 440 venous events, 115 arterial events and 7 cardiac thrombi. In 79 (29%) patients, first vascular event developed before BD diagnosis and for 77 (28%) of them, vascular involvement was the presenting sign of the disease. First relapse developed in 130 (44.7%) patients after median 24.5 (1-276) months of follow-up (TR: 46.3% (n=74), FR: 42.7% (n=56), p=0.56). Survival graph revealed that FR cohort has 1.64 times increased recurrent event risk compared to TR cohort (HR=1.64 (1.1-2.44), p=.014) and although did not reach to statistical significance, IS treatment after the first vascular event decreased further vascular events (HR= 0.66 (0.43-1.01, p=.057). Conclusion Almost half of patients relapsed of VBD within 2 years after the first vascular event. Immunosuppressants decrease VBD relapses.
dc.identifier.citationAlibaz-Oner F., Vautier M., Aksoy A., Mirouse A., Le Joncour A., Cacoub P., Ilgin C., Saadoun D., DİRESKENELİ R. H. , "Vascular Behcet's disease: a comparative study from Turkey and France", CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.40, sa.8, ss.1491-1496, 2022
dc.identifier.doi10.55563/clinexprheumatol/iovig5
dc.identifier.endpage1496
dc.identifier.issn0392-856X
dc.identifier.issue8
dc.identifier.startpage1491
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/c1973930-c791-470f-b729-d4ed810475a5/file
dc.identifier.urihttps://hdl.handle.net/11424/284079
dc.identifier.volume40
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL RHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectHealth Sciences
dc.subjectROMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectRHEUMATOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectRomatoloji
dc.subjectRheumatology
dc.subjectvascular Behcet's disease
dc.subjectrelapse
dc.subjecttreatment
dc.subjectimmunosuppressives
dc.subjectanti-coagulation
dc.subjectQUALITY-OF-LIFE
dc.subjectPOSTTHROMBOTIC SYNDROME
dc.subjectMANIFESTATIONS
dc.subjectMORTALITY
dc.subjectRISK
dc.subjectAGE
dc.titleVascular Behcet's disease: a comparative study from Turkey and France
dc.typearticle
dspace.entity.typePublication
local.avesis.idc1973930-c791-470f-b729-d4ed810475a5
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicatione995a136-8c56-4192-bebe-fe522b567ef1
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscoverye995a136-8c56-4192-bebe-fe522b567ef1

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